Genetics and Regulation (T32 GM07197)

Program DirectorLucia Rothman-Denes

Openings: 18 Predoctoral, 0 Postdoctoral

This is a broad interdisciplinary program aimed at training Ph.D. scholars in advanced rationales and methods of genetic analysis for careers as independent scientists in basic and applied biomedical research and education. Trainees may matriculate in any degree-granting unit in the division. The training faculty is comprised of members from 9 academic departments in the Division of Biological Sciences. Opportunities are available to study diverse areas of genetics, including: developmental processes; gene structure and regulation; genetic recombination and mutation; chromosome mechanics; evolution; human disease; immunology; and other areas of modern genetics. Students receive broad training in these subdisciplines while specializing in one of them for their research career. Students take courses in molecular, transmission and population/evolution genetics. The program sponsors a regularly invited seminar series, a genetics journal club, student research presentations and an annual symposium focused on areas of current interest in genetics.

Additional Information: N/A

Training Faculty

  • Rothman-Denes, Lucia: Genetics of RNA polymerase, structure and function; transcription regulation; host-phage interactions
  • Barreiro, Luis:  The intersection between the functional genomics of the immune response and evolutionary genetics
  • Bell, Graeme: Genetics of diabetes and other related diseases
  • Berg, Jeremy: Population and quantitative genetics, complex traits and diseases
  • Bishop, Douglas: Molecular mechanisms of meiotic recombination; breast cancer susceptibility genes in DNA repair
  • Chang, Eugene: Identifying genetic determinants of successful colonization and interspecies competition among gut microbes 
  • Coleman, Maureen: Population genetics and genome evolution of bacteria, bacteriophage-host interactions
  • DiRienzo, Anna: Amount and patterns of genetic variation in human populations
  • Dolan, M. Eileen: Pharmacogenetics of anticancer agents
  • Drummond, Allen: Spectrum, frequency and consequences of errors in protein synthesis, sensing and response to misfolded proteins
  • Du, Wei: The function of RB family proteins in Drosophila and dissection of the RB pathway through genetic screens
  • Dwyer, Greg: Ecology and evolution of plant-pathogen interactions
  • Eren, A. Murat: Development of novel bioinformatics tools to conduct in-depth, hypothesis driven analyses of microbial genomes, metagenomes, and metatranscriptomes
  • Fehon, Richard: Genetic analysis of cell signaling and specialized membrane domains in Drosophila
  • Ferguson, Edwin: Pattern formation and developmental genetics in Drosophila
  • Gilad, Yoav: Genetics of olfaction; inter-primate comparisons of gene expression profiles
  • Glick, Benjamin: Molecular genetic studies of Golgi biogenesis
  • Golovkina, Tatyana: Analysis of host-retrovirus interactions using genetics approaches
  • Greenberg, Jean: Plant defense mechanisms and bacterial pathogenesis
  • He, Xin: Computational and statistical methods for identification of genes involved in complex diseases and for regulatory genomics
  • Heckscher, Ellie: Focus is on the development and function of neural circuits in the motor system
  • Ho, Robert K.: Axis and pattern formation in the zebrafish embryo
  • Horne-Badovinac, Sally: Epithelial morphogenesis and organ shape
  • Kron, Stephen J.: Checkpoints, mitosis, and cyclin-dependent kinases
  • Kronforst, Marcus: Genetics basis of adaptation and speciation in butterflies using population genomics, analyses of gene expression and behavior
  • Lee, Heng-Chi: Small RNAs-medicated epigenetic regulation and genome surveillance
  • Li, Yang I: Understanding mechanisms of disease and gene regulation using computational, genetic, and molecular biology tools
  • Long, Manyuan: Origin of genes with novel functions
  • Malamy, Jocelyn: Genetics of root initiation and development
  • Marlow, Heather: Genomics, evolution and regulatory networks
  • McPeek, Mary Sara: Applications of probability and statistics to genetics
  • Moskowitz, Ivan: Molecular genetics of cardiovascular development and congenital heart disease
  • Munro, Edwin: Cytoskeletal dynamics; cell polarity; morphogenesis; computational modeling
  • Nicolae, Dan L.: Statistical genetics and the genetics of complex traits
  • Nobrega, Marcelo: Heart development and congenital heart diseases, gene regulatory architecture, vertebrate comparative genomics
  • Novembre, John: Computational approaches to study processes that shape human genetic diversity
  • Ober, Carole: Complex trait mapping in an inbred population
  • Pfister, Catherine: Species dynamics in marine ecosystems: their importance and their response to climate change
  • Pincus, David: System mechanics of cellular stress responses
  • Prince, Victoria: Pattern formation along the primary body axis of the Zebrafish embryo
  • Raghavan, Maanasa: Population and evolutionary genetics
  • Ragsdale, Clifton: Molecular genetics of neuronal patterning in brain development
  • Rebay, Ilaria: Nuclear circuitries downstream of conserved signal transduction pathways regulating critical developmental decisions
  • Rust, Michael: Biophysical and biochemical study of the architecture and robustness of biological systems; the cyanobacterial circadian clock
  • Ruthenburg, Alexander: Chromatin Biochemistry, Biophysics and Chemical Biology. Impact on epigenetics
  • Rzhetsky, Andrey: Text-mining of biomedical facts, probabilistic modeling of biological processes and genetics of complex traits
  • Schmidt-Ott, Urs: Evolution of developmental processes
  • Spitz, Francois: Genetic and molecular basis of intracellular bacterial pathogen-host interactions
  • Staley, Jonathan: Genetics of ATPases and RNA rearrangements in spliceosome activation
  • Steinrüecken, Matthias: Inferring complex demographic histories using whole-genome sequencing datasets and general selection from time series genetic data
  • Stephens, Matthew: Development of novel statistical methods for genetic analysis
  • Thornton, Joseph: Mechanisms and dynamics by which genes and the proteins they encode have evolved diverse functions
  • Turkewitz, Aaron: Genetics of regulation protein secretion in Tetrahymena
  • Wootton, John Timothy: Ecological and evolutionary consequences of interactions among organisms
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