Program Director: Louis Philipson
Administrator: Alma Farias
Openings: 0 Predoctoral, 2 Postdoctoral
The Pediatric Endocrinology Research Training Program at the University of Chicago will train pediatric physician-scientists in the investigation of endocrine diseases. This training program will help fill the national shortage of physician-scientists in the area of pediatric endocrinology. Four research training slots are requested so that two trainees can be entered annually into a two-year research training program. Thus, this program is for trainees who have had introductory laboratory and course work in their initial year of pediatric endocrinology training and have developed a research project to which they are prepared to dedicate 80% effort for the two-year training period. The training is based in a newly combined Pediatric-Adult Endocrinology, Diabetes, and Metabolism unit, the Institute for Endocrine Discovery and Clinical Care. The Senior Training Faculty numbers 15 investigators from four University departments (Medicine, Pediatrics, Human Genetics, Health Studies) who carry out a broad range of endocrine-related clinical and basic research supported by a substantial base of NIH and other peer-reviewed research grants. Each is an established investigator. In addition, the program is aided by the participation of 13 Associate Training Faculty from the Departments of Medicine, Pediatrics, Ob/Gyn and Health Studies. The University provides a rich environment of other faculty and physical resources. Trainees are selected on the basis of prior individual accomplishments including prior research training and experience as well as commitment to an academic research career. Trainees select a basic and clinical research mentor and an advisor, and the trainee and mentors jointly identify a primary and secondary research project. Trainees then undergo at least 2 years of training in the research laboratory of the preceptor(s), during which time they assume a progressively greater responsibility for developing research hypotheses, designing experiments, analyzing the data and preparing abstracts and scientific manuscripts. In the final year of training, an area of research is identified which is sufficiently different from the research of the preceptor to allow the trainee to submit a peer-reviewed mentored research grant proposal. This research training occurs within the framework of a required core curriculum consisting of courses that describe and review current research methodology and research advances as well as statistical analysis of research data. The setting is one that emphasizes translational research and timely monitoring of trainee progress.
PUBLIC HEALTH RELEVANCE: The Pediatric Endocrinology Research Training Program at the University of Chicago aims to produce highly qualified physician-scientists trained in the use of a variety of modern experimental techniques that will enable them to translate fundamental discoveries into improved medical care of diabetes and other endocrine disorders.
- Philipson, Louis: The study of ion channels, metabolism, and mitochondria that together regulate intracellular calcium concentration and energy production and thereby regulate insulin secretion in pancreatic islet beta-cells
- Bakris, George: Complications of diabetes, hypertension, and minority health issues
- Bell, Graeme: Genetics of diabetes and other related diseases
- Beyer, Eric: Ongoing studies include evaluation of the roles of hypoxia on endothelial connexins and barrier function, impact of hypoxic and other stresses on remodeling of cardiac gap junctions, and roles of oxidative stresses in the lens and cataractogenesis (and the roles of normal and mutant connexins)
- Brady, Matthew: Hormonal regulation of glycogen metabolism
- Burnet, Deborah: Community-based research to address childhood obesity and diabetes risk.
- Chin, Marshall: Improving diabetes care and outcomes for vulnerable populations
- Cohen, Ronald: Corepressor action in the pituitary and adipocyte
- Cohn, Susan: Clinical Oncology Group Trials
- Deplewski, Dianne: Sebocyte development and nuclear hormone signaling (PPAR)
- Ehrmann, David: Pathogenesis and therapy of hyperandrogenic states, genetics of insulin secretion and action in Polycystic Ovary Syndrome
- Favus, Murray: Treatment of osteoporosis and related metabolic bone disease
- Gozal, David: Pediatric sleep disorders: gene regulation in hypoxia, and genomic and proteomic approaches to clinical and epidemiological aspects of sleep in children
- Greeley, Siri: Neonatal and monogenic diabetes
- Greene, Geoffrey: Molecular mechanism of estrogen regulation of normal and cancer cell growth and development
- Grossman, Robert: Current research is focused on bioinformatics, especially developing systems, applications, and algorithms so that large genomics datasets can be integrated with phenotype information extracted from electronic medical records and analyzed to deepen understandings about human disease.
- Guandalini, Stefano: Celiac disease, and research and treatment of diarrheal diseases in children.
- Hara, Manami: Identification and characterization of the cells that define the lineage which give rise to the pancreatic beta cell
- Liao, James: Signaling mechanisms underlying cardiovascular disease
- McClintock, Martha: Biopsychology, pheromones, social behavior and the regulation of fertility, health and sexual motivation.
- Refetoff, Samuel: Thyroid hormone resistance syndromes: inherited thyroid diseases
- Rosenfield, Robert: Role of hyperandrogenism, obesity, and insulin resistance in disorders of puberty
- Ross, Lainie: Ethical and policy issues in pediatrics; human subjects protections, and transplantation
- Solway, Julian: Asthma, lung diseases, applied physiology
- Van Cauter, Eve: Role of sleep in the regulation of hormonal release and metabolism; evaluating the impact of decreased sleep duration and quality on the risk of obesity and diabetes
- Vokes, Tamara: Osteoporosis and metabolic bone disease
- White, Kevin: Research involves the application of genomics and computational approaches to investigate the development, disease and evolution of the human genome.