Trauma, Molecular Pathogenesis and Regeneration Training Grant (T32 GM99697)

Program DirectorRaphael Lee

Administrator:Helen Moey
Phone: 4-9157

Openings: 0 Predoctoral, 2 Postdoctoral

In the United States, trauma is the primary cause of human morbidity and mortality in the first four decades of life resulting in an increasing population of young people with permanent disabilities. This comes as an enormous cost. This unique training program will prepare Physician Scientists for clinical or basic/translational research careers in understanding the molecular pathogenesis and molecular regeneration of injured tissue following trauma. 

This post-doctoral training program in the field of trauma medicine is motivated by the growing integrative cross-disciplinary basic, clinical and translational research in the molecular pathogenesis and treatment of injury and is the outgrowth of well-established formal graduate courses and research programs in tissue injury and repair at the University of Chicago. Our programmatic growth is driven by the large potential clinical impact resulting from research advances into new molecular regeneration trauma therapies.

Molecular regeneration of cellular membranes and protein structure as an approach to trauma research had its beginnings at the University of Chicago more than 21 years ago and has now widely validated and emerging as a self-sustaining field of research . Today, there is sufficient established derivative research across various universities and companies. Reversing the consequences of trauma requires recovery of the lost barrier function of membranes, reformation of native macromolecular structure, control of oxygen biochemistry, nucleic acid repair, and reestablishment of metabolic energy charge. New investigators in this new field must have competencies in cellular physiology, membrane biophysics, protein chemistry, oxygen biochemistry, nucleic acid repair, animal research methods, clinical research guidelines, as well as computational and diagnostic imaging of molecular function.

Trainees will have access to an NIH grant funded super-computer with capabilities unprecedented in biomedicine to model molecular dynamics of trauma and behavior of synthetic chaperones to regenerate normal molecular structure.

Training Faculty:

  • Lee, Raphael: Copolymer surfactants for membrane sealing 
  • Alverdy, John: Bacterial pathogenesis Polymers as anti-microbial agents
  • Beiser, David: Hypothermia for prevention of reperfusion injury
  • Chen, Chin-tu: Imaging: functional, physiological, and molecular
  • Kron, Steve: Cell cycle, phosphoproteomics, cell responses to DNA damage
  • Lee, Ka Yee: Biomembranes, biophysics of protein-lipid interactions, polymer interactions with membranes
  • Marks, Jeremy: Neuronal damage and repair; polymer therapeutics for neuronal repair
  • Meredith, Stephen: Protein aggregation, amyloid structure, peptide synthesis, lipoprotein structure and function
  • Prabhakar, Nanduri: Integrative pathophysiological consequences of intermittent hypoxia
  • Sosnick, Tobin: Protein biophysics
  • Tirrell, Matthew: Biomolecular engineering and nanotechnology; manipulation and measurement of the surface properties of polymers
  • Weichselbaum, Ralph: Radiation injury, Radiation therapy
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