Publications

End-to-end prediction of clinical outcomes in head and neck squamous cell carcinoma with foundation model-based multiple instance learning.

Meneghetti AR, Hernández ML, Kuehn JP, Löck S, Carrero ZI, Perez-Lopez R, Bressem K, Brinker TK, Pearson AT, Truhn D, Nebelung S, Kather JN

End-to-end prediction of clinical outcomes in head and neck squamous cell carcinoma with foundation model-based multiple instance learning. medRxiv. 2025 Jan 25.

PMID: 39974018

PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands.

Mishra V, Singh A, Korzinkin M, Cheng X, Wing C, Sarkisova V, Koppayi AL, Pogorelskaya A, Glushchenko O, Sundaresan M, Thodima V, Carter J, Ito K, Scherle P, Trzcinska A, Ozerov I, Vokes EE, Cole G, Pun FW, Shen L, Miao Y, Pearson AT, Lingen MW, Ruggeri B, Rosenberg AJ, Zhavoronkov A, Agrawal N, Izumchenko E

PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands. J Exp Clin Cancer Res. 2025 Jan 11; 44(1):11.

PMID: 39794830

Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology.

Žigutyte L, Lenz T, Han T, Hewitt KJ, Reitsam NG, Foersch S, Carrero ZI, Unger M, Pearson AT, Truhn D, Kather JN

Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology. bioRxiv. 2025 Jan 08.

PMID: 39554184

Generative adversarial networks accurately reconstruct pan-cancer histology from pathologic, genomic, and radiographic latent features.

Howard FM, Hieromnimon HM, Ramesh S, Dolezal J, Kochanny S, Zhang Q, Feiger B, Peterson J, Fan C, Perou CM, Vickery J, Sullivan M, Cole K, Khramtsova G, Pearson AT

Generative adversarial networks accurately reconstruct pan-cancer histology from pathologic, genomic, and radiographic latent features. Sci Adv. 2024 Nov 15; 10(46):eadq0856.

PMID: 39546597

Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology.

Ramesh S, Dyer E, Pomaville M, Doytcheva K, Dolezal J, Kochanny S, Terhaar R, Mehrhoff CJ, Patel K, Brewer J, Kusswurm B, Naranjo A, Shimada H, Cipriani NA, Husain AN, Pytel P, Sokol EA, Cohn SL, George RE, Pearson AT, Applebaum MA

Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology. NPJ Precis Oncol. 2024 Nov 08; 8(1):255.

PMID: 39511421

Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology.

Žigutyte L, Lenz T, Han T, Hewitt KJ, Reitsam NG, Foersch S, Carrero ZI, Unger M, Pearson AT, Truhn D, Kather JN

Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology. bioRxiv. 2024 Nov 03.

PMID: 39554184

Developing a low-cost, open-source, locally manufactured workstation and computational pipeline for automated histopathology evaluation using deep learning.

Choudhury D, Dolezal JM, Dyer E, Kochanny S, Ramesh S, Howard FM, Margalus JR, Schroeder A, Schulte J, Garassino MC, Kather JN, Pearson AT

Developing a low-cost, open-source, locally manufactured workstation and computational pipeline for automated histopathology evaluation using deep learning. EBioMedicine. 2024 Sep; 107:105276.

PMID: 39197222

Agent-Based Modeling of Virtual Tumors Reveals the Critical Influence of Microenvironmental Complexity on Immunotherapy Efficacy.

Wang Y, Bergman DR, Trujillo E, Fernald AA, Li L, Pearson AT, Sweis RF, Jackson TL

Agent-Based Modeling of Virtual Tumors Reveals the Critical Influence of Microenvironmental Complexity on Immunotherapy Efficacy. Cancers (Basel). 2024 Aug 23; 16(17).

PMID: 39272799

Applications of artificial intelligence to myeloproliferative neoplasms: a narrative review.

Srisuwananukorn A, Krull JE, Ma Q, Zhang P, Pearson AT, Hoffman R

Applications of artificial intelligence to myeloproliferative neoplasms: a narrative review. Expert Rev Hematol. 2024 Oct; 17(10):669-677.

PMID: 39114884

Artificial Intelligence Applications in Oral Cancer and Oral Dysplasia.

Viet CT, Zhang M, Dharmaraj N, Li GY, Pearson AT, Manon VA, Grandhi A, Xu K, Aouizerat BE, Young S

Artificial Intelligence Applications in Oral Cancer and Oral Dysplasia. Tissue Eng Part A. 2024 Oct; 30(19-20):640-651.

PMID: 39041628