Publications

Ancient biases in phenotype production drove the functional evolution of a protein family.

Herrera-Álvarez S, Patton JEJ, Thornton JW

Ancient biases in phenotype production drove the functional evolution of a protein family. bioRxiv. 2025 Jan 29.

PMID: 39975351

Symmetry facilitated the evolution of heterospecificity and high-order stoichiometry in vertebrate hemoglobin.

Cortez-Romero CR, Lyu J, Pillai AS, Laganowsky A, Thornton JW

Symmetry facilitated the evolution of heterospecificity and high-order stoichiometry in vertebrate hemoglobin. Proc Natl Acad Sci U S A. 2025 Jan 28; 122(4):e2414756122.

PMID: 39847336

Robustness of ancestral sequence reconstruction to among-site evolutionary heterogeneity and epistasis.

Muñiz-Trejo R, Park Y, Thornton JW

Robustness of ancestral sequence reconstruction to among-site evolutionary heterogeneity and epistasis. bioRxiv. 2024 Dec 21.

PMID: 39763774

Symmetry facilitated the evolution of heterospecificity and high-order stoichiometry in vertebrate hemoglobin.

Cortez-Romero CR, Lyu J, Pillai AS, Laganowsky A, Thornton JW

Symmetry facilitated the evolution of heterospecificity and high-order stoichiometry in vertebrate hemoglobin. bioRxiv. 2024 Dec 13.

PMID: 39091803

On the Analysis of Protein Genetic Architecture: Response to "Protein sequence landscapes are not so simple".

Park Y, Metzger BPH, Thornton JW

On the Analysis of Protein Genetic Architecture: Response to "Protein sequence landscapes are not so simple". bioRxiv. 2024 Dec 06.

PMID: 39677708

Frequent transitions in self-assembly across the evolution of a central metabolic enzyme.

Sendker FL, Schlotthauer T, Mais CN, Lo YK, Girbig M, Bohn S, Heimerl T, Schindler D, Weinstein A, Metzger BPH, Thornton JW, Pillai A, Bange G, Schuller JM, Hochberg GKA

Frequent transitions in self-assembly across the evolution of a central metabolic enzyme. Nat Commun. 2024 Dec 03; 15(1):10515.

PMID: 39627196

The simplicity of protein sequence-function relationships.

Park Y, Metzger BPH, Thornton JW

The simplicity of protein sequence-function relationships. Nat Commun. 2024 Sep 11; 15(1):7953.

PMID: 39261454

Frequent transitions in self-assembly across the evolution of a central metabolic enzyme.

Sendker FL, Schlotthauer T, Mais CN, Lo YK, Girbig M, Bohn S, Heimerl T, Schindler D, Weinstein A, Metzger BP, Thornton JW, Pillai A, Bange G, Schuller JM, Hochberg GKA

Frequent transitions in self-assembly across the evolution of a central metabolic enzyme. bioRxiv. 2024 Jul 07.

PMID: 39005358

Epistasis facilitates functional evolution in an ancient transcription factor.

Metzger BPH, Park Y, Starr TN, Thornton JW

Epistasis facilitates functional evolution in an ancient transcription factor. Elife. 2024 May 20; 12.

PMID: 38767330

The simplicity of protein sequence-function relationships.

Park Y, Metzger BPH, Thornton JW

The simplicity of protein sequence-function relationships. bioRxiv. 2024 Feb 07.

PMID: 37732229