Publications

Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection.

Klawon DEJ, Pagane N, Walker MT, Ganci NK, Miller CH, Gai E, Rodriguez DM, Ryan-Payseur BK, Duncombe RK, Adams EJ, Maienschein-Cline M, Freitag NE, Germain RN, Wong HS, Savage PA

Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection. Science. 2025 Feb 27; eadk3248.

PMID: 40014689

The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state.

Lee V, Rodriguez DM, Ganci NK, Zeng S, Ai J, Chao JL, Walker MT, Miller CH, Klawon DEJ, Schoenbach MH, Kennedy DE, Maienschein-Cline M, Socci ND, Clark MR, Savage PA

The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state. Nat Immunol. 2023 03; 24(3):487-500.

PMID: 36759711

Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.

Chao JL, Korzinkin M, Zhavoronkov A, Ozerov IV, Walker MT, Higgins K, Lingen MW, Izumchenko E, Savage PA

Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma. Cell Rep Med. 2021 09 21; 2(9):100399.

PMID: 34622236

A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells.

Wong HS, Park K, Gola A, Baptista AP, Miller CH, Deep D, Lou M, Boyd LF, Rudensky AY, Savage PA, Altan-Bonnet G, Tsang JS, Germain RN

A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells. Cell. 2021 07 22; 184(15):3981-3997.e22.

PMID: 34157301

Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration.

Klawon DEJ, Gilmore DC, Leonard JD, Miller CH, Chao JL, Walker MT, Duncombe RK, Tung KS, Adams EJ, Savage PA

Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration. J Exp Med. 2021 06 07; 218(6).

PMID: 33914024

Eomes identifies thymic precursors of self-specific memory-phenotype CD8+ T cells.

Miller CH, Klawon DEJ, Zeng S, Lee V, Socci ND, Savage PA

Eomes identifies thymic precursors of self-specific memory-phenotype CD8+ T cells. Nat Immunol. 2020 05; 21(5):567-577.

PMID: 32284593

Regulatory T Cell Development.

Savage PA, Klawon DEJ, Miller CH

Regulatory T Cell Development. Annu Rev Immunol. 2020 04 26; 38:421-453.

PMID: 31990619

Negligible Role for Deletion Mediated by cDC1 in CD8+ T Cell Tolerance.

MacNabb BW, Kline DE, Albright AR, Chen X, Leventhal DS, Savage PA, Kline J

Negligible Role for Deletion Mediated by cDC1 in CD8+ T Cell Tolerance. J Immunol. 2019 05 01; 202(9):2628-2635.

PMID: 30902900

Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability.

Nalle SC, Zuo L, Ong MLDM, Singh G, Worthylake AM, Choi W, Manresa MC, Southworth AP, Edelblum KL, Baker GJ, Joseph NE, Savage PA, Turner JR

Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. J Clin Invest. 2019 02 01; 129(2):902-914.

PMID: 30667372

Unlocking the Complexities of Tumor-Associated Regulatory T Cells.

Chao JL, Savage PA

Unlocking the Complexities of Tumor-Associated Regulatory T Cells. J Immunol. 2018 01 15; 200(2):415-421.

PMID: 29311383