Anthony Kossiakoff is the Otho S.A. Sprague Distinguished Service Professor of Biochemistry and Molecular Biology. He is a structural biologist and protein engineer whose research group is developing a molecular understanding of how molecular recognition governs virtually all aspects of biological function. He did pioneering work towards elucidating the mechanisms involved in hormone-induced receptor activation and regulation.
To study these issues, his lab uses a combination of protein engineering, X-ray crystallography and cryo-electron microscopy, directed evolution and biophysical analysis. His group has also pioneered a new technology called “chaperone-assisted” structure determination, which has facilitated the structural analyses of protein systems that had been intractable by other approaches. Kossiakoff’s lab has also been at the forefront of developing synthetic antibodies, which are more powerful than traditional monoclonal antibodies and have the potential to replace them for uses as biotherapeutics and in cell biological applications.
Kossiakoff served as Chair of the Department of Biochemistry and Molecular Biology from 1998 to 2011 and was named as a Fellow of American Association for Advancement of Science in 2012.
Read the full story at Three UChicago faculty members elected to National Academy of Sciences in 2023
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