In the Alzheimer's affected brain, abnormal levels of the beta-amyloid protein clump together to form plaques (see in brown) that collect between neurons and disrupt cell function. Abnormal collections of the tau protein accumulate and form tangles (seen in blue) within neurons, harming synaptic communication between nerve cells. (Image: NIH)
Sangram Sisodia, PhD, the Thomas Reynolds Sr. Family Professor of Neurosciences at the University of Chicago, has received a grant for $2,322,876 over three years from philanthropic foundation Good Ventures to support research on Alzheimer's disease. Good Ventures, with support from the Open Philanthropy Act, funds scientific research that might help reduce the future burden of Alzheimer's disease.
This grant, along with grants to Massachusetts General Hospital, University of Southern California, Northwestern University and Washington University, is designed to support a collaborative group of researchers that will share knowledge and scientific tools. This collaborative group will investigate the roles of the gut and brain microbiome on Alzheimer's disease and its related symptoms in humans and mice, particularly their interactions with immune cells and genes, and influence of the blood-brain barrier on these processes. Good Ventures' total support for the collaborative is $10,468,059 over three years.
The rest of the article can be found at The Forefront.