Gastroenterologist Joseph B. Kirsner joined UChicago in 1935, then pioneered modern understanding and treatment of inflammatory bowel disease He was one of the first to show the link between ulcerative colitis and increased risk of colon cancer, introduced guidelines for how doctors should care for patients, and helped found the American Gastroenterological Association, the American Society for Gastrointestinal Endoscopy, and the American Association for the Study of Liver Diseases.
Biochemist Eugene Goldwasser isolated erythropoietin (EPO), the hormone behind red blood cell formation. The 1977 discovery led to the development of the first blockbuster drug of the biotech age, which has since treated millions with anemia.
Clifton Ragsdale, Associate Professor in the Departments of Neurobiology and Organismal Biology and Anatomy, along with Organismal Biology graduate student Caroline Albertin and a team of researchers from University of California, Berkeley and Okinawa Institute of Science and Technology sequenced the genome of the California Two-spot octopus (Octopus bimaculoides).
In a series of investigations starting in 1906, Robert R. Bensley demonstrated that the islets of Langerhans were specialized elements of the pancreas. He developed staining methods that distinguished between alpha cells and the beta cells that produce insulin. Bensley's work was fundamental to the discovery of insulin. He later developed techniques to disassemble cells and isolate cellular components by spinning them in a centrifuge, a technique he used in 1934 to isolate mitochondria.
Biochemist Donald F. Steiner, SM’56, MD’56, discovered proinsulin, the first “pro-hormone” and precursor to insulin. The 1965 finding led to the synthetic production of human insulin, markedly improving therapy for diabetes sufferers, and laid the groundwork for improved understanding of how other proteins in the body are made.
