Bryan Dickinson

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University of chicago
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Dewey JA, Dickinson BC. Split T7 RNA polymerase biosensors to study multiprotein interaction dynamics. Methods Enzymol. 2020; 641:413-432. View in: PubMed

Wei X, Adak S, Zayed M, Yin L, Feng C, Speck SL, Kathayat RS, Zhang Q, Dickinson BC, Semenkovich CF. Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease. Circ Res. 2020 Jul 03; 127(2):249-265. View in: PubMed

Zinkus-Boltz J, DeValk C, Dickinson BC. A Phage-Assisted Continuous Selection Approach for Deep Mutational Scanning of Protein-Protein Interactions. ACS Chem Biol. 2019 12 20; 14(12):2757-2767. View in: PubMed

Jones KA, Kentala K, Beck MW, An W, Lippert AR, Lewis JC, Dickinson BC. Development of a Split Esterase for Protein-Protein Interaction-Dependent Small-Molecule Activation. ACS Cent Sci. 2019 Nov 27; 5(11):1768-1776. View in: PubMed

Cao Y, Qiu T, Kathayat RS, Azizi SA, Thorne AK, Ahn D, Fukata Y, Fukata M, Rice PA, Dickinson BC. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5. Nat Chem Biol. 2019 12; 15(12):1232-1240. View in: PubMed

Azizi SA, Kathayat RS, Dickinson BC. Activity-Based Sensing of S-Depalmitoylases: Chemical Technologies and Biological Discovery. Acc Chem Res. 2019 11 19; 52(11):3029-3038. View in: PubMed

Zhou H, Rauch S, Dai Q, Cui X, Zhang Z, Nachtergaele S, Sepich C, He C, Dickinson BC. Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA. Nat Methods. 2019 12; 16(12):1281-1288. View in: PubMed

Rauch S, Dickinson BC. Expanding the Chemical Scope of RNA Base Editors. Biochemistry. 2019 08 27; 58(34):3555-3556. View in: PubMed

Zingler P, Särchen V, Glatter T, Caning L, Saggau C, Kathayat RS, Dickinson BC, Adam D, Schneider-Brachert W, Schütze S, Fritsch J. Palmitoylation is required for TNF-R1 signaling. Cell Commun Signal. 2019 08 05; 17(1):90. View in: PubMed

Rauch S, He E, Srienc M, Zhou H, Zhang Z, Dickinson BC. Programmable RNA-Guided RNA Effector Proteins Built from Human Parts. Cell. 2019 06 27; 178(1):122-134.e12. View in: PubMed

Kathayat RS, Dickinson BC. Measuring S-Depalmitoylation Activity In Vitro and In Live Cells with Fluorescent Probes. Methods Mol Biol. 2019; 2009:99-109. View in: PubMed

Rauch S, Dickinson BC. Targeted m6A reader proteins to study the epitranscriptome. Methods Enzymol. 2019; 621:1-16. View in: PubMed

Pu J, Disare M, Dickinson BC. Evolution of C-Terminal Modification Tolerance in Full-Length and Split T7 RNA Polymerase Biosensors. Chembiochem. 2019 06 14; 20(12):1547-1553. View in: PubMed

Rauch S, He C, Dickinson BC. Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs. J Am Chem Soc. 2018 09 26; 140(38):11974-11981. View in: PubMed

Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC. Correction: Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues. Chem Sci. 2017 11 01; 8(11):7879. View in: PubMed

Dickinson BC. Controlling protein function with HCV protease. Nat Methods. 2018 07; 15(7):489-490. View in: PubMed

Sadeghi RS, Kulej K, Kathayat RS, Garcia BA, Dickinson BC, Brady DC, Witze ES. Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior. Elife. 2018 04 12; 7. View in: PubMed

Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC. Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues. Chem Sci. 2017 Nov 01; 8(11):7588-7592. View in: PubMed

Kathayat RS, Cao Y, Elvira PD, Sandoz PA, Zaballa ME, Springer MZ, Drake LE, Macleod KF, van der Goot FG, Dickinson BC. Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun. 2018 01 23; 9(1):334. View in: PubMed

Rauch S, Dickinson BC. Programmable RNA Binding Proteins for Imaging and Therapeutics. Biochemistry. 2018 01 30; 57(4):363-364. View in: PubMed

Qiu T, Kathayat RS, Cao Y, Beck MW, Dickinson BC. A Fluorescent Probe with Improved Water Solubility Permits the Analysis of Protein S-Depalmitoylation Activity in Live Cells. Biochemistry. 2018 01 16; 57(2):221-225. View in: PubMed

Pu J, Kentala K, Dickinson BC. Multidimensional Control of Cas9 by Evolved RNA Polymerase-Based Biosensors. ACS Chem Biol. 2018 02 16; 13(2):431-437. View in: PubMed

Pu J, Dewey JA, Hadji A, LaBelle JL, Dickinson BC. RNA Polymerase Tags To Monitor Multidimensional Protein-Protein Interactions Reveal Pharmacological Engagement of Bcl-2 Proteins. J Am Chem Soc. 2017 08 30; 139(34):11964-11972. View in: PubMed

Pu J, Zinkus-Boltz J, Dickinson BC. Evolution of a split RNA polymerase as a versatile biosensor platform. Nat Chem Biol. 2017 04; 13(4):432-438. View in: PubMed

Kathayat RS, Elvira PD, Dickinson BC. A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling. Nat Chem Biol. 2017 02; 13(2):150-152. View in: PubMed

Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W. Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5562-71. View in: PubMed

Tomalin LE, Day AM, Underwood ZE, Smith GR, Dalle Pezze P, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ, Shanley DP, Veal EA. Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed. Free Radic Biol Med. 2016 06; 95:333-48. View in: PubMed

Pu J, Chronis I, Ahn D, Dickinson BC. A Panel of Protease-Responsive RNA Polymerases Respond to Biochemical Signals by Production of Defined RNA Outputs in Live Cells. J Am Chem Soc. 2015 Dec 30; 137(51):15996-9. View in: PubMed

Dickinson BC. Metabolism: Plugging the leak. Nat Chem Biol. 2015 Nov; 11(11):831-2. View in: PubMed

Lippert AR, Dickinson BC, New EJ. Imaging mitochondrial hydrogen peroxide in living cells. Methods Mol Biol. 2015; 1264:231-43. View in: PubMed

Dickinson BC, Packer MS, Badran AH, Liu DR. A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations. Nat Commun. 2014 Oct 30; 5:5352. View in: PubMed

Guo H, Aleyasin H, Howard SS, Dickinson BC, Lin VS, Haskew-Layton RE, Xu C, Chen Y, Ratan RR. Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes. J Biomed Opt. 2013 Oct; 18(10):106002. View in: PubMed

Lin VS, Dickinson BC, Chang CJ. Boronate-based fluorescent probes: imaging hydrogen peroxide in living systems. Methods Enzymol. 2013; 526:19-43. View in: PubMed

Dickinson BC, Lin VS, Chang CJ. Preparation and use of MitoPY1 for imaging hydrogen peroxide in mitochondria of live cells. Nat Protoc. 2013 Jun; 8(6):1249-59. View in: PubMed

Dickinson BC, Leconte AM, Allen B, Esvelt KM, Liu DR. Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9007-12. View in: PubMed

Leconte AM, Dickinson BC, Yang DD, Chen IA, Allen B, Liu DR. A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes. Biochemistry. 2013 Feb 26; 52(8):1490-9. View in: PubMed

Woolley JF, Naughton R, Stanicka J, Gough DR, Bhatt L, Dickinson BC, Chang CJ, Cotter TG. H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. PLoS One. 2012; 7(7):e34050. View in: PubMed

Dickinson BC, Chang CJ. Chemistry and biology of reactive oxygen species in signaling or stress responses. Nat Chem Biol. 2011 Jul 18; 7(8):504-11. View in: PubMed

Dickinson BC, Peltier J, Stone D, Schaffer DV, Chang CJ. Nox2 redox signaling maintains essential cell populations in the brain. Nat Chem Biol. 2011 Feb; 7(2):106-12. View in: PubMed

Dickinson BC, Huynh C, Chang CJ. A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells. J Am Chem Soc. 2010 Apr 28; 132(16):5906-15. View in: PubMed

Dickinson BC, Srikun D, Chang CJ. Mitochondrial-targeted fluorescent probes for reactive oxygen species. Curr Opin Chem Biol. 2010 Feb; 14(1):50-6. View in: PubMed

Albers AE, Dickinson BC, Miller EW, Chang CJ. A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells. Bioorg Med Chem Lett. 2008 Nov 15; 18(22):5948-50. View in: PubMed

Dickinson BC, Chang CJ. A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells. J Am Chem Soc. 2008 Jul 30; 130(30):9638-9. View in: PubMed

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Assistant Professor
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