Martin Feder

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University of Chicago
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My research focuses on understanding adaptation to the environment from both a mechanistic and evolutionary perspective; i.e., how organisms function in natural environments, the mechanisms underlying this function, the evolutionary origin, maintenance, and constraint of this function, the evolutionary consequences of variation in function, and how all of these aspects are encoded or reflected in the genome. Thus, my research focuses at the intersection of the four disciplinary domains shown to the left; i.e., evolutionary and ecological functional genomics. My research program addresses this suite of issues through a multidisciplinary, problem-oriented approach. My present emphasis is on ecological and evolutionary physiology of the stress response [the induction of a specific suite of proteins (stress or heat-shock proteins) by extreme temperatures and other stresses]. Several projects are underway, with a common theme: HEAT-SHOCK PROTEINS AND GENES Specifically, my laboratory investigates the heat-shock protein Hsp70, its encoding genes, and its regulation in Drosophila as a model system for understanding evolutionary adaptation. Hsp70 is a molecular chaperone that deters stress-induced protein aggregation, but has numerous other functions. Hsp70 is necessary for full-strength tolerance (in terms of survival, normal development, normal function) of high temperature. Such tolerance is critical in nature, where non-adult Drosophila undergo harmful to lethal high temperatures. In nature, Drosophila populations vary in stress tolerance and Hsp70 levels. Our current major focus is on understanding the genomic basis for this variation. The number of hsp70 gene copies and evolution of the hsp70 coding sequence are partial or inadequate explanations. Evidently cis-regulatory regions such as proximal promoters underlie intraspecific variation in Hsp70 levels. Repeated insertion of mobile genetic elements into these promoters is a recurrent mechanism of evolution.
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Chen B, Feder ME, Kang L. Evolution of heat-shock protein expression underlying adaptive responses to environmental stress. Mol Ecol. 2018 08; 27(15):3040-3054. View in: PubMed

Feder ME. Engineering Candidate Genes in Studies of Adaptation: The Heat-Shock Protein Hsp70 in Drosophila melanogaster. Am Nat. 1999 Jul; 154(S1):S55-S66. View in: PubMed

Krebs RA, Roberts SP, Bettencourt BR, Feder ME. Changes in thermotolerance and Hsp70 expression with domestication in Drosophila melanogaster. J Evol Biol. 2001 Jan 08; 14(1):75-82. View in: PubMed




Feder ME, Londos PL. Hydric constraints upon foraging in a terrestrial salamander, Desmognathus ochrophaeus (Amphibia: Plethodontidae). Oecologia. 1984 Nov; 64(3):413-418. View in: PubMed

Feder ME, Arnold SJ. Anaerobic metabolism and behavior during predatory encounters between snakes (Thamnophis elegans) and salamanders (Plethodon jordani). Oecologia. 1982 Apr; 53(1):93-97. View in: PubMed

Feder ME, Roberts SP, Bordelon AC. Molecular thermal telemetry of free-ranging adult Drosophila melanogaster. Oecologia. 2000 Jun; 123(4):460-465. View in: PubMed

Roberts SP, Feder ME. Natural hyperthermia and expression of the heat shock protein Hsp70 affect developmental abnormalities in Drosophila melanogaster. Oecologia. 1999 Nov; 121(3):323-329. View in: PubMed

Levin M, Anavy L, Cole AG, Winter E, Mostov N, Khair S, Senderovich N, Kovalev E, Silver DH, Feder M, Fernandez-Valverde SL, Nakanishi N, Simmons D, Simakov O, Larsson T, Liu SY, Jerafi-Vider A, Yaniv K, Ryan JF, Martindale MQ, Rink JC, Arendt D, Degnan SM, Degnan BM, Hashimshony T, Yanai I. The mid-developmental transition and the evolution of animal body plans. Nature. 2016 Mar 31; 531(7596):637-641. View in: PubMed

Hashimshony T, Feder M, Levin M, Hall BK, Yanai I. Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer. Nature. 2015 Mar 12; 519(7542):219-22. View in: PubMed

van Straalen NM, Feder ME, Sayler GS. Guest comment: Environmental genomics focus issue. Environ Sci Technol. 2012 Jan 03; 46(1):1-2. View in: PubMed

van Straalen NM, Feder ME. Ecological and evolutionary functional genomics--how can it contribute to the risk assessment of chemicals? Environ Sci Technol. 2012 Jan 03; 46(1):3-9. View in: PubMed

Feder ME. Plant and animal physiological ecology, comparative physiology/biochemistry, and evolutionary physiology: opportunities for synergy: an introduction to the symposium. Integr Comp Biol. 2002 Jul; 42(3):409-14. View in: PubMed

Tian S, Haney RA, Feder ME. Phylogeny disambiguates the evolution of heat-shock cis-regulatory elements in Drosophila. PLoS One. 2010 May 17; 5(5):e10669. View in: PubMed

Feder ME, Garland T, Marden JH, Zera AJ. Locomotion in response to shifting climate zones: not so fast. Annu Rev Physiol. 2010; 72:167-90. View in: PubMed

Feder ME. Physiology and global climate change. Annu Rev Physiol. 2010; 72:123-5. View in: PubMed

Haney RA, Feder ME. Contrasting patterns of transposable element insertions in Drosophila heat-shock promoters. PLoS One. 2009 Dec 29; 4(12):e8486. View in: PubMed

Chen B, Shilova VY, Zatsepina OG, Evgen'ev MB, Feder ME. Location of P element insertions in the proximal promoter region of Hsp70A is consequential for gene expression and correlated with fecundity in Drosophila melanogaster. Cell Stress Chaperones. 2008; 13(1):11-7. View in: PubMed

Mitchell-Olds T, Feder M, Wray G. Evolutionary and ecological functional genomics. Heredity (Edinb). 2008 Feb; 100(2):101-2. View in: PubMed

Feder ME, Madara JL. Evidence-based appointment and promotion of academic faculty at the University of Chicago. Acad Med. 2008 Jan; 83(1):85-95. View in: PubMed

Chen B, Walser JC, Rodgers TH, Sobota RS, Burke MK, Rose MR, Feder ME. Abundant, diverse, and consequential P elements segregate in promoters of small heat-shock genes in Drosophila populations. J Evol Biol. 2007 Sep; 20(5):2056-66. View in: PubMed

Feder ME. Key issues in achieving an integrative perspective on stress. J Biosci. 2007 Apr; 32(3):433-40. View in: PubMed

Feder ME. Evolvability of physiological and biochemical traits: evolutionary mechanisms including and beyond single-nucleotide mutation. J Exp Biol. 2007 May; 210(Pt 9):1653-60. View in: PubMed

Walser JC, Chen B, Feder ME. Heat-shock promoters: targets for evolution by P transposable elements in Drosophila. PLoS Genet. 2006 Oct 06; 2(10):e165. View in: PubMed

Shilova VY, Garbuz DG, Myasyankina EN, Chen B, Evgen'ev MB, Feder ME, Zatsepina OG. Remarkable site specificity of local transposition into the Hsp70 promoter of Drosophila melanogaster. Genetics. 2006 Jun; 173(2):809-20. View in: PubMed

Rashkovetsky E, Iliadi K, Michalak P, Lupu A, Nevo E, Feder ME, Korol A. Adaptive differentiation of thermotolerance in Drosophila along a microclimatic gradient. Heredity (Edinb). 2006 May; 96(5):353-9. View in: PubMed

Brown RP, Feder ME. Reverse transcriptional profiling: non-correspondence of transcript level variation and proximal promoter polymorphism. BMC Genomics. 2005 Aug 17; 6:110. View in: PubMed

Feder ME, Walser JC. The biological limitations of transcriptomics in elucidating stress and stress responses. J Evol Biol. 2005 Jul; 18(4):901-10. View in: PubMed

Velikodvorskaia VV, Lyozin GT, Feder ME, Evgen'ev MB. Unusual arrangement of the hsp68 locus in the virilis species group of Drosophila implicates evolutionary loss of an hsp68 gene. Genome. 2005 Apr; 48(2):234-40. View in: PubMed

Feder ME. Aims of undergraduate physiology education: a view from the University of Chicago. Adv Physiol Educ. 2005 Mar; 29(1):3-10. View in: PubMed

Kirkwood TB, Feder M, Finch CE, Franceschi C, Globerson A, Klingenberg CP, LaMarco K, Omholt S, Westendorp RG. What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? Mech Ageing Dev. 2005 Mar; 126(3):439-43. View in: PubMed

Lerman DN, Feder ME. Naturally occurring transposable elements disrupt hsp70 promoter function in Drosophila melanogaster. Mol Biol Evol. 2005 Mar; 22(3):776-83. View in: PubMed

Evgen'ev MB, Zatsepina OG, Garbuz D, Lerman DN, Velikodvorskaya V, Zelentsova E, Feder ME. Evolution and arrangement of the hsp70 gene cluster in two closely related species of the virilis group of Drosophila. Chromosoma. 2004 Nov; 113(5):223-32. View in: PubMed

Roberts SP, Marden JH, Feder ME. Dropping like flies: environmentally induced impairment and protection of locomotor performance in adult Drosophila melanogaster. Physiol Biochem Zool. 2003 Sep-Oct; 76(5):615-21. View in: PubMed

Feder ME, Mitchell-Olds T. Evolutionary and ecological functional genomics. Nat Rev Genet. 2003 Aug; 4(8):651-7. View in: PubMed

Garbuz D, Evgenev MB, Feder ME, Zatsepina OG. Evolution of thermotolerance and the heat-shock response: evidence from inter/intraspecific comparison and interspecific hybridization in the virilis species group of Drosophila. I. Thermal phenotype. J Exp Biol. 2003 Jul; 206(Pt 14):2399-408. View in: PubMed

Krebs RA, Feder ME. Hsp70 and larval thermotolerance in Drosophila melanogaster: how much is enough and when is more too much? J Insect Physiol. 1998 Nov; 44(11):1091-1101. View in: PubMed

Williams KD, Helin AB, Posluszny J, Roberts SP, Feder ME. Effect of heat shock, pretreatment and hsp70 copy number on wing development in Drosophila melanogaster. Mol Ecol. 2003 May; 12(5):1165-77. View in: PubMed

Lerman DN, Michalak P, Helin AB, Bettencourt BR, Feder ME. Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable elements. Mol Biol Evol. 2003 Jan; 20(1):135-44. View in: PubMed

Isaenko OA, Karr TL, Feder ME. Hsp70 and thermal pretreatment mitigate developmental damage caused by mitotic poisons in Drosophila. Cell Stress Chaperones. 2002 Jul; 7(3):297-308. View in: PubMed

Bettencourt BR, Kim I, Hoffmann AA, Feder ME. Response to natural and laboratory selection at the Drosophila hsp70 genes. Evolution. 2002 Sep; 56(9):1796-801. View in: PubMed

Feder ME, Bedford TB, Albright DR, Michalak P. Evolvability of Hsp70 expression under artificial election for inducible thermotolerance in independent populations of Drosophila melanogaster. Physiol Biochem Zool. 2002 Jul-Aug; 75(4):325-34. View in: PubMed

Bettencourt BR, Feder ME. Rapid concerted evolution via gene conversion at the Drosophila hsp70 genes. J Mol Evol. 2002 May; 54(5):569-86. View in: PubMed

Kelty JD, Noseworthy PA, Feder ME, Robertson RM, Ramirez JM. Thermal preconditioning and heat-shock protein 72 preserve synaptic transmission during thermal stress. J Neurosci. 2002 Jan 01; 22(1):RC193. View in: PubMed

Michalak P, Minkov I, Helin A, Lerman DN, Bettencourt BR, Feder ME, Korol AB, Nevo E. Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13195-200. View in: PubMed

Bujnicki JM, Feder M, Radlinska M, Rychlewski L. mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships. BMC Bioinformatics. 2001; 2:2. View in: PubMed

Zatsepina OG, Velikodvorskaia VV, Molodtsov VB, Garbuz D, Lerman DN, Bettencourt BR, Feder ME, Evgenev MB. A Drosophila melanogaster strain from sub-equatorial Africa has exceptional thermotolerance but decreased Hsp70 expression. J Exp Biol. 2001 Jun; 204(Pt 11):1869-81. View in: PubMed

Bettencourt BR, Feder ME. Hsp70 duplication in the Drosophila melanogaster species group: how and when did two become five? Mol Biol Evol. 2001 Jul; 18(7):1272-82. View in: PubMed

Feder M, Liu Z, Apostolou S, Greenberg RE, Testa JR. Loss of chromosomes 1 and X in a renal oncocytoma: implications for a possible pseudoautosomal tumor suppressor locus. Cancer Genet Cytogenet. 2000 Nov; 123(1):71-2. View in: PubMed

Lerman DN, Feder ME. Laboratory selection at different temperatures modifies heat-shock transcription factor (HSF) activation in Drosophila melanogaster. J Exp Biol. 2001 Jan; 204(Pt 2):315-23. View in: PubMed

Feder ME, Hofmann GE. Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu Rev Physiol. 1999; 61:243-82. View in: PubMed

Karr TL, Yang W, Feder ME. Overcoming cytoplasmic incompatibility in Drosophila. Proc Biol Sci. 1998 Mar 07; 265(1394):391-5. View in: PubMed

Feder ME, Krebs RA. Ecological and evolutionary physiology of heat shock proteins and the stress response in Drosophila: complementary insights from genetic engineering and natural variation. EXS. 1997; 83:155-73. View in: PubMed

Krebs RA, Feder ME. Deleterious consequences of Hsp70 overexpression in Drosophila melanogaster larvae. Cell Stress Chaperones. 1997 Mar; 2(1):60-71. View in: PubMed

Krebs RA, Feder ME. Tissue-specific variation in Hsp70 expression and thermal damage in Drosophila melanogaster larvae. J Exp Biol. 1997 Jul; 200(Pt 14):2007-15. View in: PubMed

Feder ME, CartaƱo NV, Milos L, Krebs RA, Lindquist SL. Effect of engineering Hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster. J Exp Biol. 1996 Aug; 199(Pt 8):1837-44. View in: PubMed

Feder ME, Gonzalez RJ, Robbins T, Talbot CR. Bulk flow of the medium and cutaneous sodium uptake in frogs: potential significance of sodium and oxygen boundary layers. J Exp Biol. 1993 Jan; 174:235-46. View in: PubMed

Feder ME, Seale DB, Boraas ME, Wassersug RJ, Gibbs AG. Functional conflicts between feeding and gas exchange in suspension-feeding tadpoles, Xenopus laevis. J Exp Biol. 1984 May; 110:91-8. View in: PubMed

Wassersug RJ, Feder ME. The effects of aquatic oxygen concentration, body size and respiratory behaviour on the stamina of obligate aquatic (Bufo americanus) and facultative air-breathing (Xenopus laevis and Rana berlandieri) anuran larvae. J Exp Biol. 1983 Jul; 105:173-90. View in: PubMed

Feder ME. Effect of thermal acclimation on locomotor energetics and locomotor performance in a lungless salamander, Desmognathus ochrophaeus. J Exp Biol. 1986 Mar; 121:271-83. View in: PubMed

Burggren WW, Feder ME. Effect of experimental ventilation of the skin on cutaneous gas exchange in the bullfrog. J Exp Biol. 1986 Mar; 121:445-9. View in: PubMed

Feder ME. Acclimation to constant and variable temperatures in plethodontid salamanders--I. Rates of oxygen consumption. Comp Biochem Physiol A Comp Physiol. 1985; 81(3):673-82. View in: PubMed

Pinder A, Clemens D, Feder M. An isolated perfused frog skin preparation for the study of gas exchange. Adv Exp Med Biol. 1990; 277:719-24. View in: PubMed

Pinder AW, Clemens D, Feder ME. Gas exchange in isolated perfused frog skin as a function of perfusion rate. Respir Physiol. 1991 Jul; 85(1):1-14. View in: PubMed

Clemens DT, Feder ME. Dependence of oxygen uptake on ambient PO2 in isolated perfused frog skin. J Comp Physiol B. 1992; 162(7):646-50. View in: PubMed

Feder ME, Pough FH. Temperatuer selection by the red-backed salamander, Plethodon c. cinereus (Green) (Caudata: Plethodontidae). Comp Biochem Physiol A Comp Physiol. 1975 Jan 01; 50(1A):91-8. View in: PubMed

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