Walter L. Palmer Distinguished Service Professor of Medicine and Pediatrics
Dean for Translational Medicine
Director, Institute for Translational Medicine
I am Dean for Translational Medicine and founding Director of the Institute for Translational Medicine, home of the University of Chicago-Rush University NIH/NCATS CTSA award. I have served the CTSA Consortium as a co-Chair, Steering Committee member, and co-Chair of the Strategic Goal 3 and Collaboration/Engagement Domain Task Force. My research programs primarily address asthma. I have extensive experience studying airway smooth muscle (ASM) function and dysfunction in asthma, having studied smooth muscle specific gene transcription, protein accumulation, and hypertrophy, and signaling mechanisms that regulate these; ASM contraction and its reversal, and the mechanisms that regulate these; and ASM mediated-airway narrowing, airway constrictor responsiveness, and lung function in both animal models and humans. Additional studies address asthma genetics and therapeutics in mechanistic and therapeutic clinical studies and preclinical development of novel asthma treatments. Recently, I have focused on the inhibition of pulmonary fibrosis and on the inhibition of breast cancer metastasis using novel small molecules discovered in our asthma studies. I directed the University of Chicago's NHLBI-sponsored T32 Research Training Program in Respiratory Biology for 25 years, led or co-led two NHLBI Multidisciplinary K12 Training Programs, co-led an NIH Broadening Experiences in Scientific Training (BEST) award, and currently lead a Burroughs Wellcome Fund Physician Scientist Institutional Award.
My ORCID is 0000-0002-0898-8530.
My Scopus ID is 7006796752.
My NIH COMMONS name is jsolway.
BS 1974 Massachusetts Institute of Technology (Electrical Engineering)
MD cum laude 1978 Harvard University (Medicine)
Residency 1981 Brigham and Women's Hospital (Internal Medicine)
Fellowship 1983 Harvard Medical School (Pulmonary Medicine)
Anoctamin-1 is induced by TGF-ß and contributes to lung myofibroblast differentiation.
Anoctamin-1 is induced by TGF-ß and contributes to lung myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2024 01 01; 326(1):L111-L123.
PMID: 38084409
Stress and human health in diabetes: A report from the 19th Chicago Biomedical Consortium symposium.
Stress and human health in diabetes: A report from the 19th Chicago Biomedical Consortium symposium. J Clin Transl Sci. 2023; 7(1):e263.
PMID: 38229904
The N3C governance ecosystem: A model socio-technical partnership for the future of collaborative analytics at scale.
The N3C governance ecosystem: A model socio-technical partnership for the future of collaborative analytics at scale. J Clin Transl Sci. 2023; 7(1):e252.
PMID: 38229902
Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation.
Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation. bioRxiv. 2023 Nov 09.
PMID: 37333255
Sociome Data Commons: A scalable and sustainable platform for investigating the full social context and determinants of health.
Sociome Data Commons: A scalable and sustainable platform for investigating the full social context and determinants of health. J Clin Transl Sci. 2023; 7(1):e255.
PMID: 38229897
Pharmacotherapy and pulmonary fibrosis risk after SARS-CoV-2 infection-response to Guangting Zeng and Yuchi Zhou.
Pharmacotherapy and pulmonary fibrosis risk after SARS-CoV-2 infection-response to Guangting Zeng and Yuchi Zhou. Lancet Reg Health Am. 2023 Oct; 26:100611.
PMID: 37829195
Pharmacotherapy and pulmonary fibrosis risk after SARS-CoV-2 infection: a prospective nationwide cohort study in the United States.
Pharmacotherapy and pulmonary fibrosis risk after SARS-CoV-2 infection: a prospective nationwide cohort study in the United States. Lancet Reg Health Am. 2023 Sep; 25:100566.
PMID: 37564420
Discerning asthma endotypes through comorbidity mapping.
Discerning asthma endotypes through comorbidity mapping. Nat Commun. 2022 11 07; 13(1):6712.
PMID: 36344522
Clinical and translational science and climate change: Time for action.
Clinical and translational science and climate change: Time for action. J Clin Transl Sci. 2022; 6(1):e57.
PMID: 35720971
Characterizing Long COVID: Deep Phenotype of a Complex Condition.
Characterizing Long COVID: Deep Phenotype of a Complex Condition. EBioMedicine. 2021 Dec; 74:103722.
PMID: 34839263
UChicago Dept of Medicine Distinguished Service Award
2021
American Thoracic Society Recognition Award for Scientific Accomplishment
2020
Joseph R. Rodarte Award for Scientific Distinction, Am Thoracic Soc Resp Struct & Function Assembly
2010
UChicago Dept of Medicine Arthur H. Rubenstein Mentorship Award
2008
Association of American Physicians
2005
ACP-ASIM Award for Outstanding Work in Science as Related to Medicine
2001
American Society for Clinical Investigation
1991
Tau Beta Pi
1973
Eta Kappa Nu
1973