The Novembre research group uses computational tools to study genetic diversity in natural populations. Our goal is to develop widely used statistical methods for intelligently extracting information from large-scale genomic data with the aim to improve understanding of: (1) basic genomic biology, (2) the biology of heritable disease traits, (3) the genetic basis of evolutionary processes, and (4) the history and evolution of various species, especially humans. From a disciplinary perspective, most of the ideas we use are from theoretical population genetics, statistical genetics, and computational statistics. Much of our work is invigorated by addressing data from emerging genotyping and sequencing technologies applied to large or particularly interesting population samples.
FRAME: Fine-Resolution Asymmetric Migration Estimation.
FRAME: Fine-Resolution Asymmetric Migration Estimation. Nat Commun. 2026 Jun 23; 17(1).
PMID: 42337232
Germline genetic testing and privacy concerns in patients with mesothelioma.
Germline genetic testing and privacy concerns in patients with mesothelioma. Genet Med. 2026 05; 28(5):102550.
PMID: 41795597
Reduced cyclin D3 expression in erythroid cells protects against malaria.
Reduced cyclin D3 expression in erythroid cells protects against malaria. Nature. 2026 03; 651(8106):698-706.
PMID: 41708853
When migration leaves a clean trace: Decoupling migration from coalescence in the structured serial coalescent.
When migration leaves a clean trace: Decoupling migration from coalescence in the structured serial coalescent. bioRxiv. 2025 Oct 11.
PMID: 41279837
Jointly representing long-range genetic similarity and spatially heterogeneous isolation-by-distance.
Jointly representing long-range genetic similarity and spatially heterogeneous isolation-by-distance. PLoS Genet. 2025 Sep; 21(9):e1011612.
PMID: 40956867
Study design and the sampling of deleterious rare variants in biobank-scale datasets.
Study design and the sampling of deleterious rare variants in biobank-scale datasets. Proc Natl Acad Sci U S A. 2025 Jun 10; 122(23):e2425196122.
PMID: 40460117
Fine-Resolution Asymmetric Migration Estimation.
Fine-Resolution Asymmetric Migration Estimation. bioRxiv. 2025 May 30.
PMID: 40502143
Detecting deviations from Kingman coalescence using 2-site frequency spectra.
Detecting deviations from Kingman coalescence using 2-site frequency spectra. Genetics. 2025 04 17; 229(4).
PMID: 39919046
Jointly representing long-range genetic similarity and spatially heterogeneous isolation-by-distance.
Jointly representing long-range genetic similarity and spatially heterogeneous isolation-by-distance. bioRxiv. 2025 Mar 07.
PMID: 39990319
Study design and the sampling of deleterious rare variants in biobank-scale datasets.
Study design and the sampling of deleterious rare variants in biobank-scale datasets. bioRxiv. 2025 Jan 29.
PMID: 39677632