Joseph A. Piccirilli, PhD

Crystal structure of a cap-independent translation enhancer RNA.
Crystal structure of a cap-independent translation enhancer RNA. Nucleic Acids Res. 2023 09 08; 51(16):8891-8907.
PMID: 37548413

Reinvestigating the Synthesis and Characterization of Ethyl 3-[5-(2-Ethoxycarbonyl-1-methylvinyloxy)-1-methyl-1H-indol-3-yl]-but-2-enoate.
Reinvestigating the Synthesis and Characterization of Ethyl 3-[5-(2-Ethoxycarbonyl-1-methylvinyloxy)-1-methyl-1H-indol-3-yl]-but-2-enoate. ACS Omega. 2023 Sep 05; 8(35):31941-31945.
PMID: 37692243

Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis.
Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis. Biochemistry. 2023 07 04; 62(13):2079-2092.
PMID: 37294744

A general and efficient approach to synthesize the phosphoramidites of 5'-18O labeled purine nucleosides.
A general and efficient approach to synthesize the phosphoramidites of 5'-18O labeled purine nucleosides. Nucleosides Nucleotides Nucleic Acids. 2023; 42(11):930-943.
PMID: 37233721

Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis.
Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis. J Am Chem Soc. 2023 02 08; 145(5):2830-2839.
PMID: 36706353

Demethylation of dimethyl phosphonate esters with sodium ethanethiolate: Improved synthesis of 5'-methylene substituted 2',5'-deoxyribonucleotides.
Demethylation of dimethyl phosphonate esters with sodium ethanethiolate: Improved synthesis of 5'-methylene substituted 2',5'-deoxyribonucleotides. Nucleosides Nucleotides Nucleic Acids. 2023; 42(7):538-546.
PMID: 36629008

Structural Basis for Fluorescence Activation by Pepper RNA.
Structural Basis for Fluorescence Activation by Pepper RNA. ACS Chem Biol. 2022 07 15; 17(7):1866-1875.
PMID: 35759696

Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly.
Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly. Nat Methods. 2022 05; 19(5):576-585.
PMID: 35501384

Structural basis for substrate binding and catalysis by a self-alkylating ribozyme.
Structural basis for substrate binding and catalysis by a self-alkylating ribozyme. Nat Chem Biol. 2022 04; 18(4):376-384.
PMID: 35058645

Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution.
Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution. Sci Adv. 2021 Sep 24; 7(39):eabf4459.
PMID: 34550747

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