We study the molecular mechanisms underlying membrane protein biogenesis and quality control using biochemical, structural and cell biology approaches.
UCSF
San Francisco, CA
Postdoc - Biochemistry and Biophysics
1999UCSF
San Francisco, CA
PHD - Biochemistry and Biophysics
1998Bates College
Lewiston, ME
BS - Biology and Chemistry
1990snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification.
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification. Cell. 2024 Nov 21.
PMID: 39579764The prolyl isomerase FKBP11 is a secretory translocon accessory factor.
The prolyl isomerase FKBP11 is a secretory translocon accessory factor. Mol Biol Cell. 2024 Nov 01; 35(11):ar135.
PMID: 39259761Structural analysis of the dynamic ribosome-translocon complex.
Structural analysis of the dynamic ribosome-translocon complex. Elife. 2024 Jun 18; 13.
PMID: 38896445A unifying model for membrane protein biogenesis.
A unifying model for membrane protein biogenesis. Nat Struct Mol Biol. 2024 Jul; 31(7):1009-1017.
PMID: 38811793Mechanism of an intramembrane chaperone for multipass membrane proteins.
Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature. 2022 11; 611(7934):161-166.
PMID: 36261528Substrate-driven assembly of a translocon for multipass membrane proteins.
Substrate-driven assembly of a translocon for multipass membrane proteins. Nature. 2022 11; 611(7934):167-172.
PMID: 36261522The mechanisms of integral membrane protein biogenesis.
The mechanisms of integral membrane protein biogenesis. Nat Rev Mol Cell Biol. 2022 02; 23(2):107-124.
PMID: 34556847An ER translocon for multi-pass membrane protein biogenesis.
An ER translocon for multi-pass membrane protein biogenesis. Elife. 2020 08 21; 9.
PMID: 32820719The architecture of EMC reveals a path for membrane protein insertion.
The architecture of EMC reveals a path for membrane protein insertion. Elife. 2020 05 27; 9.
PMID: 32459176Meeting the challenge of the 2019 novel coronavirus disease in patients with cancer.
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Spiess PE, Greene J, Keenan RJ, Paculdo D, Letson GD, Peabody JW. Meeting the challenge of the 2019 novel coronavirus disease in patients with cancer. Cancer. 2020 Jul 15; 126(14):3174-3175.
PMID: 32324273