We study the molecular mechanisms underlying membrane protein biogenesis and quality control using biochemical, structural and cell biology approaches.
UCSF
San Francisco, CA
Postdoc - Biochemistry and Biophysics
1999
UCSF
San Francisco, CA
PHD - Biochemistry and Biophysics
1998
Bates College
Lewiston, ME
BS - Biology and Chemistry
1990
Structural analysis of the dynamic ribosome-translocon complex.
Structural analysis of the dynamic ribosome-translocon complex. Elife. 2024 Jun 18; 13.
PMID: 38896445
A unifying model for membrane protein biogenesis.
A unifying model for membrane protein biogenesis. Nat Struct Mol Biol. 2024 May 29.
PMID: 38811793
Mechanism of an intramembrane chaperone for multipass membrane proteins.
Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature. 2022 11; 611(7934):161-166.
PMID: 36261528
Substrate-driven assembly of a translocon for multipass membrane proteins.
Substrate-driven assembly of a translocon for multipass membrane proteins. Nature. 2022 11; 611(7934):167-172.
PMID: 36261522
The mechanisms of integral membrane protein biogenesis.
The mechanisms of integral membrane protein biogenesis. Nat Rev Mol Cell Biol. 2022 02; 23(2):107-124.
PMID: 34556847
An ER translocon for multi-pass membrane protein biogenesis.
An ER translocon for multi-pass membrane protein biogenesis. Elife. 2020 08 21; 9.
PMID: 32820719
The architecture of EMC reveals a path for membrane protein insertion.
The architecture of EMC reveals a path for membrane protein insertion. Elife. 2020 05 27; 9.
PMID: 32459176
Meeting the challenge of the 2019 novel coronavirus disease in patients with cancer.
Spiess PE, Greene J, Keenan RJ, Paculdo D, Letson GD, Peabody JW. Meeting the challenge of the 2019 novel coronavirus disease in patients with cancer. Cancer. 2020 Jul 15; 126(14):3174-3175.
PMID: 32324273
A structural perspective on tail-anchored protein biogenesis by the GET pathway.
A structural perspective on tail-anchored protein biogenesis by the GET pathway. Curr Opin Struct Biol. 2018 08; 51:195-202.
PMID: 30173121
Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum.
Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum. Cell Rep. 2017 12 26; 21(13):3708-3716.
PMID: 29281821