Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.
University of Chicago
Chicago
Post-doc - Functional Genomics
2011
University of Paris VII
Paris
PhD - Population Genetics
2008
Lusófona University
Lisbon
Master - Biotechnological Engineering
2003
A female-biased gene expression signature of dominance in cooperatively breeding meerkats.
A female-biased gene expression signature of dominance in cooperatively breeding meerkats. Mol Ecol. 2024 Jul 17; e17467.
PMID: 39021304
High-throughput screen identifies non inflammatory small molecule inducers of trained immunity.
High-throughput screen identifies non inflammatory small molecule inducers of trained immunity. Proc Natl Acad Sci U S A. 2024 Jul 16; 121(29):e2400413121.
PMID: 38976741
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity. Nat Commun. 2024 May 16; 15(1):4177.
PMID: 38755196
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection.
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection. PLoS Biol. 2024 Apr; 22(4):e3002259.
PMID: 38683873
Shaping immunity: The influence of natural selection on population immune diversity.
Shaping immunity: The influence of natural selection on population immune diversity. Immunol Rev. 2024 May; 323(1):227-240.
PMID: 38577999
Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination.
Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination. Immunol Lett. 2024 Jun; 267:106851.
PMID: 38479480
EpiVar Browser: advanced exploration of epigenomics data under controlled access.
EpiVar Browser: advanced exploration of epigenomics data under controlled access. Bioinformatics. 2024 Mar 04; 40(3).
PMID: 38449289
Epigenetic variation impacts individual differences in the transcriptional response to influenza infection.
Epigenetic variation impacts individual differences in the transcriptional response to influenza infection. Nat Genet. 2024 Mar; 56(3):408-419.
PMID: 38424460
DNA methylation-environment interactions in the human genome.
DNA methylation-environment interactions in the human genome. Elife. 2024 Feb 26; 12.
PMID: 38407202
Microbial transmission in the social microbiome and host health and disease.
Microbial transmission in the social microbiome and host health and disease. Cell. 2024 01 04; 187(1):17-43.
PMID: 38181740