Dr. Faubert leads a research laboratory focused on understanding how metabolic reprogramming—alterations in metabolic flux within malignant cells—supports cancer cell survival, growth, and progression. The Faubert lab has extensive expertise in both in vitro and in vivo metabolic analysis, including the direct measurement of tumor metabolism intra-operatively in patients.
To achieve a comprehensive understanding of metabolic pathways in cancer, Dr. Faubert's team employs a wide array of mass spectrometry platforms alongside advanced methodologies such as isotope tracing (13C, 2H), metabolomics, and metabolic flux analysis. These tools allow the lab to dissect the metabolic programs driving malignant phenotypes at both cellular and systemic levels.
Complementing these biochemical techniques, the lab also uses molecular imaging technologies to noninvasively monitor tumor metabolic states in vivo. This dual approach enables the investigation of metabolic heterogeneity across different tumor types and stages. Recent work from Dr. Faubert’s laboratory is exploring the metabolic alterations that occur during the metastatic cascade, aiming to uncover novel vulnerabilities that can be therapeutically targeted.
UT Southwestern
Dallas
Postdoc - Cancer Metabolism
2021
McGill University
Montreal
PhD - Physiology
2015
Mannose supports lung cancer metabolism during glycolytic limitation.
Mannose supports lung cancer metabolism during glycolytic limitation. EMBO Rep. 2026 Sep; 27(18):5365-5381.
PMID: 42567946
Reductive carboxylation via isocitrate dehydrogenase 1 supports cardiac metabolic adaptation during oncometabolic stress.
Reductive carboxylation via isocitrate dehydrogenase 1 supports cardiac metabolic adaptation during oncometabolic stress. bioRxiv. 2026 Jun 10.
PMID: 42327104
l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression.
l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression. J Clin Invest. 2026 May 01; 136(9).
PMID: 41842973
A Stable Isotope Tracing Primer for the Mass Spectrometrist.
A Stable Isotope Tracing Primer for the Mass Spectrometrist. Annu Rev Anal Chem (Palo Alto Calif). 2026 05; 19(1):1-23.
PMID: 41701910
Now you serine, now you don't.
Now you serine, now you don't. Trends Pharmacol Sci. 2025 11; 46(11):1047-1048.
PMID: 41077509
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts.
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts. Nat Metab. 2025 Aug; 7(8):1703-1713.
PMID: 40731149
L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression.
L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression. bioRxiv. 2025 Jun 24.
PMID: 40667135
Approaches to stable isotope tracing and in vivo metabolomics in the cancer clinic.
Approaches to stable isotope tracing and in vivo metabolomics in the cancer clinic. EMBO J. 2025 Jun; 44(12):3303-3306.
PMID: 40355557
High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients.
High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients. Cancer Discov. 2025 Apr 02; 15(4):702-716.
PMID: 39960461
Beyond glucose and Warburg: finding the sweet spot in cancer metabolism models.
Beyond glucose and Warburg: finding the sweet spot in cancer metabolism models. NPJ Metab Health Dis. 2024 Sep 02; 2(1):11.
PMID: 40603611