The primary research interest of the Faubert laboratory is investigating how metabolic reprogramming – alterations of metabolic flux in malignant cells – supports cancer cell survival and growth. We have extensive experience in measuring metabolism in vitro and in vivo, including measuring tumor metabolism intra-operatively in patients. The laboratory utilizes a series of mass spectrometry platforms to provide comprehensive views of metabolic pathways in biological systems. We use a variety of methods to assess metabolism, including isotope tracing (13C, 2H, etc.), metabolomics and metabolic flux to dissect the metabolic programs that underlie these malignant phenotypes. We complement these approaches with molecular imaging techniques to monitor metabolic states of tumor metabolism in vivo, in order to understand the breadth of metabolic diversity in cancer. Emerging work from the lab explores the metabolic alterations that occur during the metastatic cascade, and the tumor metabolism that results unique microenvironments.
UT Southwestern
Dallas
Postdoc - Cancer Metabolism
2021
McGill University
Montreal
PhD - Physiology
2015
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer.
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer. Nat Metab. 2024 Jun 14.
PMID: 38877143
Electron transport chain inhibition increases cellular dependence on purine transport and salvage.
Electron transport chain inhibition increases cellular dependence on purine transport and salvage. Cell Metab. 2024 Jul 02; 36(7):1504-1520.e9.
PMID: 38876105
Severely polarized extracellular acidity around tumour cells.
Severely polarized extracellular acidity around tumour cells. Nat Biomed Eng. 2024 Jun; 8(6):787-799.
PMID: 38438799
Metabolic signatures of thymomas: potential biomarkers and treatment targets.
Metabolic signatures of thymomas: potential biomarkers and treatment targets. Eur J Cardiothorac Surg. 2024 Feb 01; 65(2).
PMID: 38011656
Metabolic Signatures of Thymomas: Potential Biomarkers and Treatment Targets.
Metabolic Signatures of Thymomas: Potential Biomarkers and Treatment Targets. Eur J Cardiothorac Surg. 2023 Nov 27.
PMID: 38011656
Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity.
Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity. Nature. 2023 Nov; 623(7989):1034-1043.
PMID: 37993715
Metabolic pathway analysis using stable isotopes in patients with cancer.
Metabolic pathway analysis using stable isotopes in patients with cancer. Nat Rev Cancer. 2023 Dec; 23(12):863-878.
PMID: 37907620
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis.
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis. Nat Metab. 2023 09; 5(9):1563-1577.
PMID: 37653041
Electron transport chain inhibition increases cellular dependence on purine transport and salvage.
Electron transport chain inhibition increases cellular dependence on purine transport and salvage. bioRxiv. 2023 May 11.
PMID: 37214913
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma.
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Sci Adv. 2022 12 16; 8(50):eabp8293.
PMID: 36525494