The Kron laboratory is a diverse and collaborative group of cell biologists, geneticists, biochemists, chemists and computer scientists. Our current basic research and technology efforts include 1) defining roles for chromatin dynamics and cell cycle regulation in DNA damage checkpoint response and cellular senescence, 2) dissecting cross-talk between metabolism and DNA damage response, 3) developing novel molecular assays to interrogate cell signaling in cancer, and 4) implementing novel mass spectrometry approaches to enable quantitative proteomics. We also pursue translational projects directed at 1) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization, 2) examining DNA damage and repair in tissues and tumors, and 3) exploiting DNA damage responses to induce anti-tumor immune responses.
Stephen J. Kron, MD PhD
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Professor of Molecular Genetics and Cell Biology
Committee on Cancer Biology
Committee on Clinical Pharmacology and Pharmacogenomics
Committee on Genetics, Genomics and Systems Biology - Research and Scholarly Interests: Checkpoints, Cell Cycle, DNA Repair, Immunotherapy, Radiotherapy, Senescence, Cell, Systems Biology
- Websites: Department of Molecular Genetics & Cell Biology, Faculty Profile, Kron Lab, Research Network Profile
- Contact: skron@uchicago.edu
- Graduate Programs: Cancer Biology, Cell & Molecular Biology, Genetics, Genomics & Systems Biology, UChicago Biosciences