Medical Scientist National Research Service Award (T32 GM07281)

Program DirectorMarcus Clark

Executive Director, Associate Dean of Students: Kristin McCann
Phone: 4-3661

Openings: 22 M.D./Ph.D., 0 Predoctoral, 0 Postdoctoral

The Medical Scientist Training Program is an integrated program of study leading to the MD degree and to the PhD in a field related to medicine under the auspices of the Interdisciplinary Scientists Training Program (ISTP). Students admitted to the program begin in the summer quarter at the end of June with the newly-developed Intro to Basic and Translational Science Research course, and later in the summer join their medical school classmates for The Human Body (Anatomy) and Health Care Disparities in America. During the school year students enroll in the Pritzker Initiative and in a graduate curriculum specific to their research interests (with concentrations available in Immunology, Molecular Pathology & Molecular Medicine, Microbiology, Cancer Biology, and Neurobiology) and including a year-long, MSTP-specific Journal Club. During the second summer, trainees rotate through one or two laboratories to determine their specific area of research interest and select their potential faculty adviser. While some students make this choice early and begin thesis research after the first year of medical studies, most trainees enter into full time research toward the PhD after the second year of medical studies is completed, taking additional courses only as needed to meet degree requirements. After completion of the PhD, trainees return to finish the remainder of their medical program.

Training Faculty:

  • Clark, Marcus: Immunity in the pathogenesis of human autoimmune diseases
  • Adams, Erin: T cell receptor recognition
  • Alegre, Maria-Luisa: T cell responses in transplantation, autoimmunity and cancer
  • Alverdy, John: Pseudomonas' effect on the gut barrier
  • Arac-Ozkan, Demet: Mechanism by which adhesion-type Gprotein coupled receptors (GPCRs) function in the brain
  • Armato, Samuel: Computerized techniques for the quantitative analysis of thoracic CT scans
  • Bendelac, Albert: NKT cell interactions with lipid antigens in vivo
  • Bensmaia, Sliman: Neural basis of perception and neoroprosthetics
  • Bezanilla, Francisco: Structural studies of K+ channel gating
  • Bishop, Douglas: Mechanisms of homologous recombination and genome instability
  • Cheng, Jason: G​enetic and epigenetic controls of hematopoiesis, hematopietic stem cell differentiation and lineage specification; Pathogenesis of anemia and leukemia
  • Chin, Marshall: Translational research to improve diabetes care for vulnerable populations
  • Chong, Anita: Transplantation tolerance and infection; Multidisciplinary effort to develop adjuvant-free vaccines for infectious diseases
  • Cobey, Sarah: Diversity and evolution of pathogens and pathogen communities
  • de Jong, Jill: Genetic regulation of hematopoietic stem cells and the genes that result in hemato-poietic malignancies
  • de Wit, Harriet: Behavioral and subjective effects of drugs of abuse in humans
  • Di Rienzo, Anna: Patterns of genetic variation in human populations
  • Dinner, Aaron: How complex biological behavior arises from molecular interactions
  • Dolan, M. Eileen: Pharmacogenomics of anticancer agents
  • Du, Wei: Control of cell proliferation, differentiation, and cell cycle arrest
  • Dumitrescu, Alexandra: Identifying inherited genetic mutations that may cause thyroid disease
  • Dwyer, Gregory: Ecology & evolution of infectious diseases especially on how mathematical models can explicate disease dynamics
  • Freedman, David: Neuronal mechanisms underlying visual learning, categorization and decision-making
  • Gajewski, Thomas: Mechanisms of control of anti-tumor immune responses from within the tumor micro-environment.
  • Gardel, Margaret: Regulation of contractile cytoskeleton in non-muscle cells
  • Giger, Maryellen: Computer-aided diagnosis, image based risk assessment, and quantitative image analysis in the areas of breast cancer, lung cancer, and bone disease
  • Gilad, Yoav: Genetic basis of human-specific traits, including sysceptibility to certain diseases and disorders
  • Godley, Lucy: The role of 5-hydroxymethylcytosince, the newly discovered "six DNA base" in leukemia and hematopoietic cell differentiation
  • Golovkina, Tatyana: Virology of retrovirus-host interactions
  • Gomez, Christopher: Diagnosis, treatment, and research of degenerative ataxias
  • Greene, Geoffrey: Breast cancer biology and therapies
  • Grossman, Robert: Using clouds to manage and analyze the large datasets produced by next gen sequencing
  • Grove, Elizabeth: Molecular mechanisms that set up the neocortical area map
  • Hale, Melina: Organization, function and development of neural circuits that control locomotion
  • Halpern, Howard: Develop high resolution noninvasive images of oxygen distributions in tumors and normal tissues living animals
  • Hansel, Christian: Intrinsic plasticity and information storage in cerebellar Purkinje cells
  • Hassan, Hatim: Molecular mechanisms regulating SLC26A6 and how this might pertain to the risk of kidney disease
  • Hatsopoulos, Nicholas: Coding of action by motor and premotor cortical ensembles
  • He, Chuan: Chemistry and mechanism of DNA/RNA repair and modification systems; Virulence and antibiotic resistance regulation 
  • He, Tong Chuan: BMP and Wnt regulated osteogenic differentiation of mesenchymal stem cells
  • Hofmann-Bowman, Marion: Blood vessel inflammation mediated by activation of RAGE
  • Horne-Badovinac, Sally: Genetic analysis of epithelial morphogenesis and organ shape
  • Jabri, Bana: Regulation of Memory/Effector T Cell Mediated Immune Responses; Interface between innate and adaptive immunity
  • Jiang, Yulei: Development of computer-aided methods for the detection and diagnosis of breast cancer
  • Kee, Barbara: Regulation of early lymphocyte development
  • Keedy, Sarah: Cognitive and emotional neural systems overlap in patients with psychiatric disorders as well as in healthy individuals
  • Keenan, Robert: Cellular pathways that direct membrane protein biogenesis and fluorescent proteins engineering
  • Konetzka, Rita T.: Health Economics; Effects of financing & market structure; Medicare & Medicaid policy, long term care, health workforce issues
  • Kovar, David: Self-organization of the functionally diverse actin cytoskeleton
  • Krishnan,Yamuna: Structure & dynamics of unusual forms of nucleic acids; creating nucleic acid-based nanodevices for applications in biology
  • Kron, Stephen: DNA damage, response, detection and treatment
  • La Riviere, Patrick: Develop image reconstruction methods optimized for specific non-contrast CT applications
  • LaBelle, James: Target intracellular proteins to induce cancer cell death and control immune response
  • Lahn, Bruce: Molecular basis of cell fate restriction
  • Lauderdale, Diane: Health of immigrant populations and social determinants of health-related behaviors 
  • LeBeau, Michelle: Characterizing the cytogenetic, clinical, and morphologic features of therapy-related acute myeloid leukemia
  • Lee, Ka Yee: Lipid-Cholesterol Interactions in Membranes
  • Lengyel, Ernst Robert: Treatment and biology of ovarian cancer 
  • MacLean, Jason: Cellular basis for information storage in cortical circuits
  • Macleod, Kay: Role of mitochondrial dysfunction and oxidative stress in tumor progression 
  • Margoliash, Daniel: Motor control, learning and memory
  • Mason, Peggy: Physiology of Raphe Magnus cells during wake and sleep
  • McGehee, Daniel: Nicotinic receptors and addictions
  • McNerney, Megan: Genomics of acute myeloid leukemias
  • Meltzer, David: The theoretical foundations of medical costeffectiveness analysis and the cost and quality of hospital care
  • Meredith, Stephen: Protein aggregation and amyloid structure associated with Alzheimer's Disease and Cerebral Amyloid Angiopathy
  • Missiakas, Dominique: Pathogenesis of human and animal S. aureas infections
  • Moellering, Raymond: Study of complexity and dynamics in the proteome
  • Moskowitz, Ivan: Genetic and molecular analysis of mouse mutants with congenital heart defects
  • Nelson, Debbie: Physiology of Cl- channels in peripheral cells and in brain
  • Nobrega, Marcelo: Architecture and function of genes
  • Nusbaum, Howard: Cognitive engineering and human factors
  • Ober, Carol: Sex-specific genetic architecture of asthmaassociated quantitative traits
  • Olopade, Olufunmilayo: Detection of early onset breast cancer
  • Pan, Tao: Function and regulation of t-RNA modifications
  • Peek, Monica: Patient/provider communication, its implications for diabetes health disparities
  • Perozo, Eduardo: Energy transduction mechanisms in ion channels
  • Piccirilli, Joseph: Identification and characterization of catalytic metal ions within RNA 
  • Popko, Brian: Myelinating glial cell development
  • Prince, Victoria: Studies of hindbrain patterning, neuronal migration, and endoderm regionalization
  • Ragsdale, Cliff: Cellular and molecular organization of the octopus brain
  • Randall, Glenn: Roles of virus-host interactions in replication and pathogenesis
  • Rebay, Ilaria: Cross-talk between signal transduction pathways and tissue specific transcriptional networks
  • Reid, Russell: Craniofacial tissue engineering
  • Rice, Phoebe: Structure and biochemistry of DNA recombination proteins
  • Rothman-Denes, Lucia: Structure, promoter interaction and regulation of three DNA-dependent RNA polymerases
  • Rust, Michael: Microbial cell metabolism and behaviour 
  • Rzhetsky, Andrey: Large-scale analysis of genetic overlaps between neuro-psychiatric phenotypes
  • Savage, Peter: Mechanisms regulating immune response to cancer
  • Schwartz, Nancy: Brain development, dysfunction and mental retardation
  • Segal, Jeremy: Genomics approaches for early cancer detection
  • Sherman, Murray: Information processing in sensory system
  • Sisodia, Sangram: Molecular mechanisms of Alzheimer's disease
  • Solway, Julian: Airway inflammation in asthma
  • Sosnick, Tobin: Biophysics of protein folding
  • Sperling, Ann: Development and persistence of inflammation in a murine model of asthma
  • Thinakaran, Gopal: Mechanisms that regulate Alzheimer's disease -amyloid (A) production and deposition
  • VanDrongelen, Wim: Neural processing and epileptiform activity patterns.
  • Zhuang, Xiaoxi: Role of dopamine in modulating information processing in motor learning, motor performance, reward learning and motivation
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