Medical Scientist National Research Service Award (T32 GM07281)

Program DirectorMarcus Clark

Dean of Students: Alison Anastasio
Phone: 4-3661
Fax: 4-3999

Openings: 20 M.D./Ph.D., 0 Predoctoral, 0 Postdoctoral

The Medical Scientist Training Program is an integrated program of study leading to the MD degree and to the PhD in a field related to medicine under the auspices of the Interdisciplinary Scientists Training Program (ISTP). Students admitted to the program begin in the summer quarter at the end of June with the newly-developed Intro to Basic and Translational Science Research course, and later in the summer join their medical school classmates for The Human Body (Anatomy) and Health Care Disparities in America. During the school year students enroll in the Pritzker Initiative and in a graduate curriculum specific to their research interests (with concentrations available in Immunology, Molecular Pathology & Molecular Medicine, Microbiology, Cancer Biology, and Neurobiology) and including a year-long, MSTP-specific Journal Club. During the second summer, trainees rotate through one or two laboratories to determine their specific area of research interest and select their potential faculty adviser. While some students make this choice early and begin thesis research after the first year of medical studies, most trainees enter into full time research toward the PhD after the second year of medical studies is completed, taking additional courses only as needed to meet degree requirements. After completion of the PhD, trainees return to finish the remainder of their medical program.

Training Faculty:

  • Clark, Marcus: Immunity in the pathogenesis of human autoimmune diseases
  • Adams, Erin: T cell receptor recognition
  • Alegre, Maria-Luisa: T cell responses in transplantation, autoimmunity and cancer
  • Alverdy, John: Pseudomonas' effect on the gut barrier
  • Armato, Samuel: Computerized techniques for the quantitative analysis of thoracic CT scans
  • Aydogan, Bulent: Development of novel CT image contrast agents
  • Bendelac, Albert: NKT cell interactions with lipid antigens in vivo
  • Bensmaia, Sliman: Neural basis of perception and neoroprosthetics
  • Bezanilla, Francisco: Structural studies of K+ channel gating
  • Bishop, Douglas: Mechanisms of homologous recombination and genome instability
  • Bubeck Wardenburg, Juliane: Virulence factors in mediating Staph. aureas infections
  • Chen, Chin-Tu: Development of molecular imagining methods as tools for investigation of cancer, neurological disorders, and cardiovascular diseases.
  • Chin, Marshall: Translational research to improve diabetes care for vulnerable populations
  • Cohn, Susan: Role of angiogenesis in neuroblastoma pathogenesis
  • Crosson, Sean: Mechanisms of prokaryotic signal transduction
  • Dawson, Glyn: Identifying bioactive sphingolipid components of cells and lipid rafts
  • de Jong, Jill: Genetic regulation of hematopoietic stem cells and the genes that result in hemato-poietic malignancies
  • de Wit, Harriet: Behavioral and subjective effects of drugs of abuse in humans
  • Di Rienzo, Anna: Patterns of genetic variation in human populations
  • Dolan, M. Eileen: Genetic determinants associated with pemetrexed response and toxity
  • Du, Wei: Control of cell proliferation, differentiation, and cell cycle arrest
  • Dwyer, Gregory: Host-pathogen coevolution in driving insect outbreaks
  • Freedman, David: Neuronal mechanisms underlying visual learning, categorization and decision-making
  • Gajewski, Thomas: Mechanisms of control of anti-tumor immune responses from within the tumor micro-environment.
  • Gardel, Margaret: Regulation of contractile cytoskeleton in non-muscle cells.
  • Giger, Maryellen: Computer-aided diagnosis, image based risk assessment, and quantitative image analysis in the areas of breast cancer, lung cancer, and bone disease.
  • Godley, Lucy: The role of 5-hydroxymethylcytosince, the newly discovered "six DNA base" in leukemia and hematopoietic cell differentiation
  • Golovkina, Tatyana: Virology of retrovirus-host interactions
  • Gomez, Christopher: Diagnosis, treatment, and research of degenerative ataxias
  • Grdina, David: Radiation protectors and radiation therapy coupled chemprevention
  • Greene, Geoffrey: Breast cancer biology and therapies
  • Grossman, Robert: Using clouds to manage and analyze the large datasets produced by next gen sequencing
  • Grove, Elizabeth: Molecular mechanisms that set up the neocortical area map
  • Hale, Melina: Organization, function and development of neural circuits that control locomotion
  • Halpern, Howard: Develop high resolution noninvasive images of oxygen distributions in tumors and normal tissues living animals
  • Hanck, Dorothy: Electrophysiological, molecular biological, and modeling of basic biophysics, physiology, and molecular pharmacology of ion channels important in controlling cell excitability in health and disease
  • Hansel, Christian: Intrinsic plasticity and information storage in cerebellar Purkinje cells
  • Hatsopoulos, Nicholas: Coding of action by motor and premotor cortical ensembles
  • He, Chuan: Chemistry and mechanism of DNA/RNA repair and modification systems
  • He, Tong Chuan: BMP and Wnt regulated osteogenic differentiation of mesenchymal stem cells
  • Horne-Badovinac, Sally: Genetic analysis of epithelial morphogenesis and organ shape
  • Huang, R. Stephanie: Genome-wide genetic screening for anti-cancer drug sensitivity prediction
  • Jiang, Yulei: Development of computer-aided methods for the detection and diagnosis of breast cancer
  • Karczmar, Gregory: Applications of MRI to diagnose and guide treatment of breast cancer
  • Kay, Leslie: Olfactory behavioral electro-physiology and olfactory psychophysics in small rodents
  • Kee, Barbara: Regulation of early lymphocyte development
  • Keenan, Kathryn: Depression in preadolescent girls
  • Keenan, Robert: Cellular pathways that direct membrane protein biogenesis and fluorescent proteins engineering
  • Kovar, David: Self-organization of the functionally diverse actin cytoskeleton
  • Kron, Stephen: DNA damage, response, detection and treatment
  • Kumar, Vinay: Signaling in natural killer cells
  • Lahn, Bruce: Molecular basis of cell fate restriction
  • LaRiviere, Patrick: Develop image reconstruction methods optimized for specific non-contrast CT applications
  • Lauderdale, Diane: Health of immigrant populations and social determinants of health-related behaviors 
  • LeBeau, Michelle: Characterizing the cytogenetic, clinical, and morphologic features of therapy-related acute myeloid leukemia
  • Lee, Ka Yee: Lipid-Cholesterol Interactions in Membranes
  • Lee, Raphael: Molecular biophysics of trauma induced tissue injury
  • Lengyel, Ernst Robert: Treatment and biology of ovarian cancer 
  • MacLean, Jason: Cellular basis for information storage in cortical circuits
  • Macleod, Kay: Role of mitochondrial dysfunction and oxidative stress in tumor progression 
  • Margoliash, Daniel: Behavioral and neuro-physiological mechanisms of state modulation in bird song
  • Marino, Susana: Transplantation immunobiology
  • Mason, Peggy: Physiology of Raphe Magnus cells during wake and sleep
  • McGehee, Daniel: Nicotinic receptors and addictions
  • Meltzer, David: The theoretical foundations of medical costeffectiveness analysis and the cost and quality of hospital care
  • Meredith, Stephen: Protein aggregation and amyloid structure associated with Alzheimer's Disease and Cerebral Amyloid Angiopathy
  • Missiakas, Dominique: Pathogenesis of human and animal S. aureas infections
  • Moffat, Keith: Structural biology of light-sensing proteins
  • Moskowitz, Ivan: Genetic and molecular analysis of mouse mutants with congenital heart defects
  • Nelson, Debbie: Physiology of Cl- channels in peripheral cells and in brain
  • Ober, Carol: Sex-specific genetic architecture of asthmaassociated quantitative traits
  • Olopade, Olufunmilayo: Detection of early onset breast cancer
  • Onel, Kenan: Genome-wide association studies to identify prognostic genetic biomarkers for cancer
  • Pan, Tao: Function and regulation of t-RNA modifications
  • Peek, Monica: Patient/provider communication, its implications for diabetes health disparities
  • Perozo, Eduardo: Molecular mechanisms of gating in voltagedependent channels
  • Piccirilli, Joseph: Identification and characterization of catalytic metal ions within RNA 
  • Popko, Brian: Myelinating glial cell development
  • Prendergast, Brian: Communication of circadian and seasonal biological timekeeping systems with the immune system
  • Prince, Victoria: Studies of hindbrain patterning, neuronal migration, and endoderm regionalization
  • Ragsdale, Cliff: Cellular and molecular organization of the octopus brain
  • Rebay, Ilaria: Cross-talk between signal transduction pathways and tissue specific transcriptional networks
  • Rice, Phoebe: Structure and biochemistry of DNA recombination proteins
  • Rinker-Schaeffer, Carrie: Metastatic colonization in prostate and ovarian cancers
  • Rothman-Denes, Lucia: Structure, promoter interaction and regulation of three DNA-dependent RNA polymerases
  • Rzhetsky, Andrey: Large-scale analysis of genetic overlaps between neuro-psychiatric phenotypes
  • Schneewind, Olaf: The mechanisms and strategies whereby pathogenic bacteria cause human disease
  • Schuger, Lucia: Genetic program of smooth muscle myogenesis and the pathogenesis of cardiovascular disease and asthma
  • Schwartz, Nancy: Brain development, dysfunction and mental retardation
  • Sherman, Murray: Information processing in sensory system
  • Sisodia, Sangram: Molecular mechanisms of Alzheimer's disease
  • Solway, Julian: Airway inflammation in asthma
  • Sosnick, Tobin: Biophysics of protein folding
  • Sperling, Ann: Development and persistence of inflammation in a murine model of asthma
  • Thinakaran, Gopal: Mechanisms that regulate Alzheimer's disease -amyloid (A) production and deposition
  • Turner, Jerrold: Physiological regulation of intestinal epithelial transport and barrier function
  • VanDrongelen, Wim: Neural processing and epileptiform activity patterns.
  • Vezina, Paul: Neurochemical and morpho-logical events in brain that underlie drug-induced behavioral plasticity
  • Weigert, Martin: Genetics and regulation of autoantibodies
  • White, Kevin: Transcriptional networks in the control of development, evolution and disease
  • William, Shellie: Methods of care for Alzheimer's patients
  • Zhuang, Xiaoxi: Role of dopamine in modulating information processing in motor learning, motor performance, reward learning and motivation
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