Research Training in Respiratory Biology (T32 HL07605)

Program DirectorAnne Sperling and Julian Solway

Administrator: Juanita Tyler
Phone: 2-6790
Fax: 2-4736

Openings: 0 Predoctoral, 10 Postdoctoral

The objective of this research training program for Ph.D. or M.D. trainees is to produce scientists whose basic investigations in cell and molecular biology elucidate the pathophysiology of human respiratory disease and critical illness. The program focuses primarily on Airway Biology and on Endothelial Cell Biology. Areas of training include: cell and molecular biology of airway and vascular tissue components; mechanisms of inflammation; tissue remodeling and growth; immunology; and organ physiology. Formal coursework, research presentations, and clinical exposure, coupled with laboratory investigation, provide broad experience designed to facilitate transition to the trainees’ independent research careers.

Training Faculty:

  • Sperling, AnneThe immunology of lung diseases
  • Solway, JulianAirway Smooth Muscle Asthma; Translational Medicine
  • Adams, Erin: Molecular Immunology​
  • Adegunsoye, AyodejiImpact of telomere lengths in Pulmonary Fibrosis
  • Alegre, Maria-LuisaInduction and antagonism of transplantation tolerance
  • Alverdy, John: Life-threatening infections following trauma, major surgery, and during critical illness
  • Bendelac, AlbertThe development and function of innate lymphocytes
  • Chang, Eugene B.: Host-microbe interactions in immune development and metabolic regulation
  • Chong, AnitaImmunological tolerance and humoral immunity in allogeneic transplantation
  • Clark, MarcusImmunity in the pathogenesis of human autoimmune diseases
  • Dulin, NickolaiSignaling mechanisms of myofibroblast differentiation and pulmonary fibrosis
  • Fang, YunNon-coding RANs in Vascular Pathophysiology
  • Gilad, Yoav: Human genetics, gene regulation, and genome biology
  • Gounairi, Fotini: Signal transduction pathways involved in the development of hematopoietic stem cells into the T-cell lineage and deregulations that lead to leukemia​
  • Grossman, Robert: Informatics and Data Intensive Computing
  • Guzy, Robert: Mechanisms of FGF2 signaling in pulmonary fibrosis
  • Huang, Elbert: Health services and translational research questions at the intersection of aging, diabetes, and health economics​
  • Hubbell, Jeffrey: Molecular bioengineering, regenerative medicine, and engineering immunity​
  • Konetzka, R. Tamara: Health economics, long-term care; effects of financing and market structure on quality of care; Medicare and Medicaid policy; health workforce issues.
  • Kress, JohnOptimizing outcomes in mechanically ventilated ICU patients
  • Meltzer, DavidHealth economics and public policy; theoretical foundations of medical cost-effectiveness analysis; determinants of the cost/quality of hospital care
  • Mokhlesi, Babak: Cardiometabolic risk associated with obstructive sleep apnea (OSA), REM sleep apnea, and insomnia
  • Mutlu, Gokhan:  Mechanisms of lung injury, repair and fibrosis
  • Nagler, Cathryn: Mechanisms governing tolerance to dietary antigens and the potential immunomodulato ry features of this route of antigen administration​
  • Ober, CaroleGenetic, epigenetic, and genomic studies of asthma
  • Olopade, ChristopherAsthma-Environment and genetics; Global Health: Household air pollution, health and epigenetics
  • Patel, BhaktiIdentify patient care interventions that mitigate or prevent long-term complications of critical illness​
  • Prabhakar, NanduriHypoxic sensing by carotid body chemoreceptors and autonomic functions
  • Ross, Lainie FriedmanResearch ethics; ethical and policy issues in Cystic Fibrosis newborn screening
  • Rzhetsky, Andrey: Modeling of genetic data in the context of molecular networks, with focus on autism, bipolar disorder, schizophrenia, and Alzheimer’s disease​
  • Strek, MaryDiagnosis and treatment of chronic lung disease
  • Swartz, MelodyLymphatic vessels and their transport functions in inflammation and immunity
  • Thompson, EmmaGenetics of airway hyper-responsiveness 
  • Tasali, EsraRole of insufficient sleep in the development of metabolic diseases such as diabetes and obesity​
  • Tay, SavasExamining how signaling pathways control cellular decision- making​
  • White, StevenRegulation of airway repair after injury
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