The main focus of my research is to understand the mechanisms by which RNAs mediate gene expression and regulation in both bacterial and eukaryotic systems. We are currently studying regulatory RNAs and RNA modifications using various single-molecule fluorescence microscopy and super-resolution imaging tools. my group is also interested in the development of new labeling, imaging and data analysis methods.
Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts.
Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts. bioRxiv. 2024 May 02.
PMID: 38659805
RNA molecules display distinctive organization at nuclear speckles.
RNA molecules display distinctive organization at nuclear speckles. iScience. 2024 May 17; 27(5):109603.
PMID: 38638569
Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency.
Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency. bioRxiv. 2024 Feb 29.
PMID: 38464148
KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.
KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions. Nat Biotechnol. 2024 Jan 18.
PMID: 38238480
Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing.
Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing. Nat Methods. 2024 Feb; 21(2):247-258.
PMID: 38200227
Comparative genetic, biochemical, and biophysical analyses of the four E. coli ABCF paralogs support distinct functions related to mRNA translation.
Comparative genetic, biochemical, and biophysical analyses of the four E. coli ABCF paralogs support distinct functions related to mRNA translation. bioRxiv. 2023 Jun 12.
PMID: 37398404
Entropic control of the free-energy landscape of an archetypal biomolecular machine.
Entropic control of the free-energy landscape of an archetypal biomolecular machine. Proc Natl Acad Sci U S A. 2023 05 23; 120(21):e2220591120.
PMID: 37186858
Deep learning modeling m6A deposition reveals the importance of downstream cis-element sequences.
Deep learning modeling m6A deposition reveals the importance of downstream cis-element sequences. Nat Commun. 2022 05 17; 13(1):2720.
PMID: 35581216
Kinetic modeling reveals additional regulation at co-transcriptional level by post-transcriptional sRNA regulators.
Kinetic modeling reveals additional regulation at co-transcriptional level by post-transcriptional sRNA regulators. Cell Rep. 2021 09 28; 36(13):109764.
PMID: 34592145
Binding of the RNA Chaperone Hfq on Target mRNAs Promotes the Small RNA RyhB-Induced Degradation in Escherichia coli.
Binding of the RNA Chaperone Hfq on Target mRNAs Promotes the Small RNA RyhB-Induced Degradation in Escherichia coli. Noncoding RNA. 2021 Sep 28; 7(4).
PMID: 34698252
Kavli Fellow
National Academy of Sciences
2024
Scialog Fellow
Research Corporation for Science Advancement
2018
NIH Director’s New Innovator Award
NIH
2017 - 2022
Searle Scholar
Searle Scholars Program
2017 - 2020
Hammett Award
Columbia University
2010
Blanche R. and David Kasindorf Fellowship Award
Columbia University
2007