Matthias Steinruecken, PhD

Assistant Professor of Ecology and Evolution
Assistant Professor of Human Genetics
Committee on Genetics, Genomics and Systems Biology
Research and Scholarly Interests: Mathematical Biology, Population Genetics, Statistical Genetics
Websites: Lab Site, Research Network Profile
Contact: steinrue@uchicago.edu
Graduate Programs: Ecology & Evolution, Genetics, Genomics & Systems Biology, Committee on Evolutionary Biology, Human Genetics, UChicago Biosciences

In my research, I develop computational and statistical methods for population genomics analysis to investigate the forces underlying evolution and genetic variation in populations. Specifically, some things we work on are inferring demographic histories, and studying adaptation using ancient DNA or time series genetic data.

Technical University Berlin
Berlin
PhD - Mathematics
2009

Bielefeld University
Bielefeld
Diplom - Computer Science
2006

Population Genomic Scans for Natural Selection and Demography.
Population Genomic Scans for Natural Selection and Demography. Annu Rev Genet. 2024 Sep 03.
PMID: 39227130

Inference of population history using coalescent HMMs: review and outlook.
Inference of population history using coalescent HMMs: review and outlook. Curr Opin Genet Dev. 2018 12; 53:70-76.
PMID: 30056275

Model-based detection and analysis of introgressed Neanderthal ancestry in modern humans.
Model-based detection and analysis of introgressed Neanderthal ancestry in modern humans. Mol Ecol. 2018 10; 27(19):3873-3888.
PMID: 29603507

Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans.
Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans. Nature. 2018 01 11; 553(7687):203-207.
PMID: 29323294

Computing the joint distribution of the total tree length across loci in populations with variable size.
Computing the joint distribution of the total tree length across loci in populations with variable size. Theor Popul Biol. 2017 12; 118:1-19.
PMID: 28943126

The Effects of Population Size Histories on Estimates of Selection Coefficients from Time-Series Genetic Data.
The Effects of Population Size Histories on Estimates of Selection Coefficients from Time-Series Genetic Data. Mol Biol Evol. 2016 11; 33(11):3002-3027.
PMID: 27550904

SpectralTDF: transition densities of diffusion processes with time-varying selection parameters, mutation rates and effective population sizes.
SpectralTDF: transition densities of diffusion processes with time-varying selection parameters, mutation rates and effective population sizes. Bioinformatics. 2016 03 01; 32(5):795-7.
PMID: 26556388

POPULATION GENETICS. Genomic evidence for the Pleistocene and recent population history of Native Americans.
POPULATION GENETICS. Genomic evidence for the Pleistocene and recent population history of Native Americans. Science. 2015 Aug 21; 349(6250):aab3884.
PMID: 26198033

Transition Densities and Sample Frequency Spectra of Diffusion Processes with Selection and Variable Population Size.
Transition Densities and Sample Frequency Spectra of Diffusion Processes with Selection and Variable Population Size. Genetics. 2015 Jun; 200(2):601-17.
PMID: 25873633

A NOVEL SPECTRAL METHOD FOR INFERRING GENERAL DIPLOID SELECTION FROM TIME SERIES GENETIC DATA.
A NOVEL SPECTRAL METHOD FOR INFERRING GENERAL DIPLOID SELECTION FROM TIME SERIES GENETIC DATA. Ann Appl Stat. 2014 Dec; 8(4):2203-2222.
PMID: 25598858

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Postdoctoral Research Fellowship
German Research Foundation (DFG)
2011 - 2013

Ph.D. Fellowship, International Research Training Group
TU Berlin
2006 - 2009