Our research aims to uncover the grammar – or general rules – governing how successful immune responses work to stop an infection or remove diseased cells while keeping the host healthy at the end of the process. We emphasize a multiscale approach that parallels the organization of the immune system across the body from molecules and cells to tissues to the whole organism. By creating new tools and approaches, we study how interactions occur between immunological components across these scales to uncover fundamental concepts in immunology and beyond. We pursue this goal in the hope that it will contribute knowledge to the longstanding question of how to manipulate the immune system at will.
Harvard Medical School
Boston, USA
Ph.D. - Immunology
2012
Université de la Méditerranée
Marseille, France
M.S. - Biochemistry, Immunology
2007
Université de Bourgogne
Dijon, France
B.S. - Biochemistry
2005
Secreted phospholipase PLA2G5 acts as a hemolytic factor in sepsis.
Secreted phospholipase PLA2G5 acts as a hemolytic factor in sepsis. J Clin Invest. 2026 May 01; 136(9).
PMID: 42065235
Whole-body molecular and cellular mapping of the laboratory mouse.
Whole-body molecular and cellular mapping of the laboratory mouse. Cell. 2026 May 28; 189(11):3481-3498.e24.
PMID: 41903540
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control.
Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control. Nat Cell Biol. 2025 Oct; 27(10):1812-1826.
PMID: 40957911
Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation.
Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation. Nature. 2025 07; 643(8071):509-518.
PMID: 40533562
Mammalian Queuosine tRNA Modification Impacts Translation to Enhance Cell Proliferation and MHC-II Expression.
Mammalian Queuosine tRNA Modification Impacts Translation to Enhance Cell Proliferation and MHC-II Expression. J Mol Biol. 2025 Aug 15; 437(16):169188.
PMID: 40339980
IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis.
IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis. Immunity. 2025 05 13; 58(5):1306-1326.e7.
PMID: 40306274
Repurposing large-format microarrays for scalable spatial transcriptomics.
Repurposing large-format microarrays for scalable spatial transcriptomics. Nat Methods. 2025 Jan; 22(1):145-155.
PMID: 39562752
A pairwise cytokine code explains the organism-wide response to sepsis.
A pairwise cytokine code explains the organism-wide response to sepsis. Nat Immunol. 2024 Feb; 25(2):226-239.
PMID: 38191855
Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation.
Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation. bioRxiv. 2023 Feb 02.
PMID: 36778287
Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons.
Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons. Nat Commun. 2021 11 18; 12(1):6715.
PMID: 34795271