Raghu G. Mirmira, MD, PhD, is a physician–scientist specializing in diabetes, β-cell biology, and translational endocrinology. He is a tenured Professor of Medicine at the University of Chicago, where he serves as Director of the NIH-funded Diabetes Research and Training Center and Vice Chair for Research in the Department of Medicine. He completed his MD and PhD training at the University of Chicago, followed by residency and fellowship training at the University of California, San Francisco, where he was a Howard Hughes Physician Postdoctoral Fellow.
Dr. Mirmira’s research focuses on understanding the mechanisms that lead to pancreatic β-cell dysfunction and loss in diabetes. His laboratory has examined transcriptional control of β-cell identity, inflammatory pathways including 12-lipoxygenase, and stress-response mechanisms affecting β-cell survival. His group has also contributed to the development of biomarkers that reflect β-cell stress and injury in individuals with or at risk for type 1 diabetes. His work spans molecular and cellular approaches, human islet studies, and translational investigations aimed at informing new therapeutic strategies.
He has maintained continuous NIH funding for more than two decades and serves as PI or MPI on multiple NIH R01, U01, and P30 grants. He is an elected member of the American Society for Clinical Investigation and the Association of American Physicians, and he received the Albert Renold Award from the American Diabetes Association for contributions to mentorship and training. In addition to his research program, Dr. Mirmira remains active in clinical endocrinology at UChicago
The demise of islet allotransplantation in the United States: A call for an urgent regulatory update.
The demise of islet allotransplantation in the United States: A call for an urgent regulatory update. Am J Transplant. 2021 04; 21(4):1365-1375.
PMID: 33251712
Author Correction: Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation.
Author Correction: Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation. Sci Rep. 2021 Jan 04; 11(1):249.
PMID: 33397990
Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention.
Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention. Metabolites. 2020 Dec 18; 10(12).
PMID: 33353164
Hypusination Orchestrates the Antimicrobial Response of Macrophages.
Hypusination Orchestrates the Antimicrobial Response of Macrophages. Cell Rep. 2020 12 15; 33(11):108510.
PMID: 33326776
The Demise of Islet Allotransplantation in the US: A Call for an Urgent Regulatory Update The "ISLETS FOR US" Collaborative.
Witkowski P, Philipson L, Kaufman DB, Ratner L, Abouljoud MS, Bellin M, Buse J, Kandeel F, Stock P, Mulligan D, Markmann JF, Kozlowski T, Andreoni K, Alejandro R, Baidal D, Hardy MA, Wickrema A, Mirmira RG, Fung J, Becker Y, Josephson MA, Bachul PJ, Pyda JS, Charlton M, Millis JM, Gaglia J, Stratta RJ, Fridell JA, Niederhaus S, Forbes RC, Jayant K, Robertson RP, Odorico J, Levy M, Harland R, Abrams PL, Olaitan OK, Kandaswamy R, Wellen J, Japour AJ, Desai CS, Naziruddin B, Balamurugan AN, Barth RN, Ricordi C. The Demise of Islet Allotransplantation in the US: A Call for an Urgent Regulatory Update The "ISLETS FOR US" Collaborative. Am J Transplant. 2020 Nov 29.
PMID: 33251712
Phenotypic sexual dimorphism in response to dietary fat manipulation in C57BL/6J mice.
Phenotypic sexual dimorphism in response to dietary fat manipulation in C57BL/6J mice. J Diabetes Complications. 2021 02; 35(2):107795.
PMID: 33308894
Probing islet stress in type 1 diabetes.
Probing islet stress in type 1 diabetes. Aging (Albany NY). 2020 Oct 12; 12(19):18795-18796.
PMID: 33048839
A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish.
A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish. FASEB J. 2020 11; 34(11):14850-14862.
PMID: 32918516
The role of beta-cell dysfunction in early type 1 diabetes.
The role of beta-cell dysfunction in early type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2020 08; 27(4):215-224.
PMID: 32618633
Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.
Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes. Clin Epigenetics. 2020 07 31; 12(1):116.
PMID: 32736653