Using high-throughput genomic data, Riesenfeld Group develops approaches to computationally infer the circuits that regulate gene expression and cellular function. By iterating experimental perturbations, data modeling, and targeted validations, they aim to extract from noisy, large-scale data the signals to help answer complex questions about the immune system, such as: What drives tolerant versus inflammatory immune responses? How do immune pathways contribute to or disrupt tissue homeostasis? How can immune responses be manipulated to restore health?
Eomes expression identifies the early bone marrow precursor to classical NK cells.
Eomes expression identifies the early bone marrow precursor to classical NK cells. Nat Immunol. 2024 Jul; 25(7):1172-1182.
PMID: 38871999
Quantum computing for oncology.
Quantum computing for oncology. Nat Cancer. 2024 Jun; 5(6):811-816.
PMID: 38760645
Dissection and integration of bursty transcriptional dynamics for complex systems.
Dissection and integration of bursty transcriptional dynamics for complex systems. Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18):e2306901121.
PMID: 38669186
Dissection and Integration of Bursty Transcriptional Dynamics for Complex Systems.
Dissection and Integration of Bursty Transcriptional Dynamics for Complex Systems. bioRxiv. 2023 Jun 13.
PMID: 37398022
GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology.
GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. Immunity. 2023 01 10; 56(1):43-57.e10.
PMID: 36630917
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell. 2022 10 27; 185(22):4190-4205.e25.
PMID: 36243004
Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling.
Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling. Immunity. 2022 09 13; 55(9):1663-1679.e6.
PMID: 36070768
A cellular and spatial map of the choroid plexus across brain ventricles and ages.
A cellular and spatial map of the choroid plexus across brain ventricles and ages. Cell. 2021 05 27; 184(11):3056-3074.e21.
PMID: 33932339
Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Skin-resident innate lymphoid cells converge on a pathogenic effector state. Nature. 2021 04; 592(7852):128-132.
PMID: 33536623
Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide a-CGRP Modulates Group 2 Innate Lymphoid Cell Responses.
Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide a-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 10 15; 51(4):696-708.e9.
PMID: 31618654