Broadly, my group investigates the coevolution of pathogens and hosts’ adaptive immunity. We use computational and mathematical tools to test hypotheses and to advance theory. Our earlier work focused on the evolutionary consequences of immune-mediated competition between different pathogen strains, including pneumococcus, human papillomavirus, and especially influenza. More recently, our focus has expanded to include the related dynamics of the host immune response. We are investigating the evolution of antibody repertoires within hosts over time, in particular to identify the roles of infection history, chance, vaccination, and host genetics in generating the diversity of B cell responses. This research involves linking epidemiological and immunological observations of B cells to the antigenic and genetic evolution of influenza viruses. Consequently, it makes extensive use of longitudinal dynamical models of individuals and birth cohorts as well as techniques from molecular evolution to investigate coevolution across scales.
Understanding the dynamics of vaccination is another area of focus. We have investigated the actual and expected impacts of vaccines against pneumococcus, human papillomavirus, and influenza. With influenza, we have been investigating the impact of the vaccine on viral transmission and local evolution and how immune history might reduce the vaccine’s effectiveness and alter selective pressures. Improving vaccination strategies given hosts’ diverse immune histories and the potential for rapid evolution by the pathogen is a long-term aim of our work. Ultimately, we want to explain coevolution sufficiently well to enable prediction, or at least to determine when prediction is not feasible.
Harvard School of Public Health
Postdoctoral - Infectious disease dynamics
2013
University of Michigan, Ann Arbor
PhD - Ecology & Evolution
2009
Princeton University
AB - Ecology & Evolution
2002
Preliminary Findings From the Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE I) Study: A Randomized Controlled Trial.
Preliminary Findings From the Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE I) Study: A Randomized Controlled Trial. Clin Infect Dis. 2024 Oct 15; 79(4):901-909.
PMID: 39041887
Predicting pathogen mutual invasibility and co-circulation.
Predicting pathogen mutual invasibility and co-circulation. Science. 2024 Oct 11; 386(6718):175-179.
PMID: 39388572
Measures of population immunity can predict the dominant clade of influenza A (H3N2) in the 2017-2018 season and reveal age-associated differences in susceptibility and antibody-binding specificity.
Measures of population immunity can predict the dominant clade of influenza A (H3N2) in the 2017-2018 season and reveal age-associated differences in susceptibility and antibody-binding specificity. medRxiv. 2024 Oct 10.
PMID: 37961288
Vaccination against rapidly evolving pathogens and the entanglements of memory.
Vaccination against rapidly evolving pathogens and the entanglements of memory. Nat Immunol. 2024 Nov; 25(11):2015-2023.
PMID: 39384979
High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains.
High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains. J Virol. 2024 Oct 22; 98(10):e0068924.
PMID: 39315814
A speed limit on serial strain replacement from original antigenic sin.
A speed limit on serial strain replacement from original antigenic sin. Proc Natl Acad Sci U S A. 2024 Jun 18; 121(25):e2400202121.
PMID: 38857397
Preliminary findings from the Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE I) Study: a Randomized Controlled Trial.
Preliminary findings from the Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE I) Study: a Randomized Controlled Trial. medRxiv. 2024 May 17.
PMID: 38798684
Reduced effectiveness of repeat influenza vaccination: distinguishing among within-season waning, recent clinical infection, and subclinical infection.
Reduced effectiveness of repeat influenza vaccination: distinguishing among within-season waning, recent clinical infection, and subclinical infection. J Infect Dis. 2024 Apr 30.
PMID: 38687898
A speed limit on serial strain replacement from original antigenic sin.
A speed limit on serial strain replacement from original antigenic sin. bioRxiv. 2024 Apr 20.
PMID: 38260288
Reduced effectiveness of repeat influenza vaccination: distinguishing among within-season waning, recent clinical infection, and subclinical infection.
Reduced effectiveness of repeat influenza vaccination: distinguishing among within-season waning, recent clinical infection, and subclinical infection. medRxiv. 2024 Apr 10.
PMID: 37016669
Neubauer Faculty Development Fellowship
University of Chicago
2016
James S. McDonnell Foundation Complex Systems Scholar Award
University of Chicago
2014
NIH New Innovator Award
University of Chicago
2014
NIH Kirchstein National Research Service Award
Harvard School of Public Health
2011
NSF Graduate Research Fellowship
University of Michigan
2005
Sigma Xi Society
Princeton University
2002
Phi Beta Kappa
Princeton University
2002
Senior Book Prize, Ecology & Evolution
Princeton University
2002